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Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
It is found that high-frequency stimulation of the perforant path-granule cell (pp-gc) synapse markedly increases zif/268 messenger RNA levels in the ipsilateral granule cell neurons; mRNA of c-fos, c-jun and jun-B is less consistently increased.
Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females.
The results demonstrate the sensitivity and specificity of DNA testing for FLN1 mutations and have important functional implications for models ofFLN1 protein function in neuronal migration.
Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial
To demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partial
Constitutive expression of zif268 in neocortex is regulated by synaptic activity.
It is demonstrated that this "constitutive" expression of the transcription factor zif268 in cortex is driven by natural synaptic activity, suggesting that transcription factors play a role not only in responses to artificial stimuli but also in the normal maintenance of cortical physiology.
Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
This study provides Class IV evidence that for adults with medically refractory partial onset seizures, responsive direct cortical stimulation reduces seizures and improves quality of life over a mean follow-up of 5.4 years.
Status Epilepticus and Periictal Imaging
  • A. Cole
  • Medicine
  • 1 July 2004
A framework is proposed for considering the relation between ictal duration and severity, the characteristics of imaging abnormalities, and the mechanism of their underlying pathophysiology.
Silent Hippocampal Seizures and Spikes Identified by Foramen Ovale Electrodes in Alzheimer’s Disease
The findings in these index cases support a model in which early development of occult hippocampal hyperexcitability may contribute to the pathogenesis of AD.
Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity.
It is reported that PD098059, a selective inhibitor of the calcium-activated p44/42 mitogen-activated protein kinase (MAP kinase) pathway, reduces neuronal death in a cell-culture model of seizure activity and suggests a heretofore unknown function for the p 44/42 MAP kinase pathway in neurons.