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Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
RECENT studies in invertebrates indicate that a rapid genomic response to neuronal stimulation has a critical role in long-term changes in synaptic efficacy1. Because several of the genesExpand
Mutations in ABHD12 cause the neurodegenerative disease PHARC: An inborn error of endocannabinoid metabolism.
Polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and cataract (PHARC) is a neurodegenerative disease marked by early-onset cataract and hearing loss, retinitis pigmentosa, and involvementExpand
Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females.
Periventricular heterotopia (PH) is a human neuronal migration disorder in which many neurons destined for the cerebral cortex fail to migrate. Previous analysis showed heterozygous mutations in theExpand
Constitutive expression of zif268 in neocortex is regulated by synaptic activity.
Transcription factors are rapidly and transiently induced in brain by excitatory stimuli and may be important in coordinating changes in gene expression underlying neuronal plasticity. In contrast toExpand
Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial
To demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partialExpand
Long-term treatment with responsive brain stimulation in adults with refractory partial seizures
Objective: The long-term efficacy and safety of responsive direct neurostimulation was assessed in adults with medically refractory partial onset seizures. Methods: All participants were treated withExpand
Status Epilepticus and Periictal Imaging
  • A. Cole
  • Medicine
  • Epilepsia
  • 1 July 2004
Summary:  Peri‐ and postictal changes on both anatomic and functional imaging examinations have been recognized for many years. With the wide availability of magnetic resonance imaging and positronExpand
Cryptogenic New Onset Refractory Status Epilepticus (NORSE) in adults—Infectious or not?
INTRODUCTION In the majority of cases of New Onset Refractory Status Epilepticus (NORSE) in adults, a cause is discovered. However, some cases of NORSE remain undiagnosed, i.e. cryptogenic. They areExpand
Convulsant-induced increase in transcription factor messenger RNAs in rat brain.
Administration of the convulsants pentylenetetrazole (Metrazole) or picrotoxin to rats caused a dramatic increase in mRNAs of four putative transcription factor genes, zif/268, c-jun, jun-B, andExpand
Inhibition of the p44/42 MAP kinase pathway protects hippocampal neurons in a cell-culture model of seizure activity.
Excessive release of glutamate and the subsequent influx of calcium are associated with a number of neurological insults that result in neuronal death. The calcium-activated intracellular signalingExpand