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Widespread transcription at neuronal activity-regulated enhancers
It is revealed that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis, which occurs specifically at enhancers that are actively engaged in promoting mRNA synthesis.
Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites
Inhibition of Activity-Dependent Arc Protein Expression in the Rat Hippocampus Impairs the Maintenance of Long-Term Potentiation and the Consolidation of Long-Term Memory
Investigation of the role of the IEGArc in hippocampal plasticity shows that disruption of Arc protein expression impairs the maintenance phase of LTP without affecting its induction and impairs consolidation of LTM for spatial water task training without affecting task acquisition or short-term memory.
Homer: a protein that selectively binds metabotropic glutamate receptors
A novel dendritic protein, Homer, is reported that contains a single, PDZ-like domain and binds specifically to the carboxy terminus of phosphoinositide-linked metabotropic glutamate receptors, suggesting that Homer mediates a novel cellular mechanism that regulates glutamate signalling.
Environment-specific expression of the immediate-early gene Arc in hippocampal neuronal ensembles
Following sequential exposure of rats to two different environments or to the same environment twice, the proportion of CA1 neurons with cytoplasmic, nuclear or overlapping Arc expression profiles matched predictions derived from ensemble neurophysiological recordings of hippocampal neuronal ensembles.
Coupling of mGluR/Homer and PSD-95 Complexes by the Shank Family of Postsynaptic Density Proteins
GRIP: a synaptic PDZ domain-containing protein that interacts with AMPA receptors
GRIP is a new member of the PDZ domain-containing protein family which has seven PDZ domains and no catalytic domain and appears to serve as an adapter protein that links AMPA receptors to other proteins and may be critical for the clustering of AMPA receptor at excitatory synapses in the brain.
Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
Homer Binds a Novel Proline-Rich Motif and Links Group 1 Metabotropic Glutamate Receptors with IP3 Receptors