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Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
It is found that high-frequency stimulation of the perforant path-granule cell (pp-gc) synapse markedly increases zif/268 messenger RNA levels in the ipsilateral granule cell neurons; mRNA of c-fos, c-jun and jun-B is less consistently increased. Expand
Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1
The role of the schizophrenia risk factor DISC1 in the maintenance of spine morphology and function was found to be anchored Kalirin-7 (Kal-7), regulating access to Rac1 and controlling the duration and intensity of Rac1 activation in response to NMDA receptor activation in both cortical cultures and rat brain in vivo. Expand
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.
Results suggest that actions of inositol 1,4,5-trisphosphate are regulated by physiological alterations in intracellular pH and calcium concentrations. Expand
Spontaneous synchronous synaptic calcium transients in cultured cortical neurons
The firing pattern displayed by neuronal aggregates is thought to play a key role in cortical development and physiology. In this study, we have employed optical recording of intracellular calcium toExpand
Constitutive expression of zif268 in neocortex is regulated by synaptic activity.
It is demonstrated that this "constitutive" expression of the transcription factor zif268 in cortex is driven by natural synaptic activity, suggesting that transcription factors play a role not only in responses to artificial stimuli but also in the normal maintenance of cortical physiology. Expand
Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons
It is found that glutathione depletion leads to hypercondensation and fragmentation of chromatin into spherical or irregular shapes, a morphologic signature of apoptosis, which suggests that oxidative stress can induce apoptosis in neurons. Expand
Solubilization, purification, and characterization of an inositol trisphosphate receptor.
The purified receptor is globular with a Stokes' radius of approximately 10 nm, and electrophoretic analysis reveals one protein band with an Mr of 260,000, while binding is reversibly inhibited by 300 nM calcium in particulate fractions and detergent-solubilized membranes, the purified protein is not inhibited by calcium concentrations up to 1.5 mM. Expand
Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B
Observations define a cell type-specific, transcription factor signaling pathway necessary for SV- induced apoptosis, and the precise mechanism by which Bcl-2 and thiol agents inhibit SV-induced nuclear NF-kappa B activity in AT-3 cells may provide insights into the pluripotent antiapoptotic actions of these agents. Expand
Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists
Abstract Previous pharmacological studies have suggested that the firing activity of 5-HT cells of the dorsal raphe nucleus is dependent on a tonically active, central adrenergic system. In thisExpand