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Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation
It is found that high-frequency stimulation of the perforant path-granule cell (pp-gc) synapse markedly increases zif/268 messenger RNA levels in the ipsilateral granule cell neurons; mRNA of c-fos, c-jun and jun-B is less consistently increased.
Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1
The role of the schizophrenia risk factor DISC1 in the maintenance of spine morphology and function was found to be anchored Kalirin-7 (Kal-7), regulating access to Rac1 and controlling the duration and intensity of Rac1 activation in response to NMDA receptor activation in both cortical cultures and rat brain in vivo.
Constitutive expression of zif268 in neocortex is regulated by synaptic activity.
- P. Worley, B. Christy, Y. Nakabeppu, R. Bhat, A. Cole, J. Baraban
- BiologyProceedings of the National Academy of Sciences…
- 15 June 1991
It is demonstrated that this "constitutive" expression of the transcription factor zif268 in cortex is driven by natural synaptic activity, suggesting that transcription factors play a role not only in responses to artificial stimuli but also in the normal maintenance of cortical physiology.
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.
Rapid Communication: Oxidative Stress Induces Apoptosis in Embryonic Cortical Neurons
It is found that glutathione depletion leads to hypercondensation and fragmentation of chromatin into spherical or irregular shapes, a morphologic signature of apoptosis, which suggests that oxidative stress can induce apoptosis in neurons.
Serotonergic and non-serotonergic neurons of the dorsal raphe: reciprocal changes in firing induced by peripheral nerve stimulation
Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists
Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation
- C. Chiaruttini, A. Vicario, E. Tongiorgi
- BiologyProceedings of the National Academy of Sciences
- 22 September 2009
It is found that the coding region common to all BDNF transcripts contains a constitutively active dendritic targeting signal and that this signal is suppressed in transcripts containing exons 1 or 4, which are restricted to the cell soma and proximal dendrites.
Solubilization, purification, and characterization of an inositol trisphosphate receptor.
Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B
- K. Lin, S. H. Lee, R. Narayanan, J. Baraban, J. Hardwick, R. Ratan
- BiologyJournal of Cell Biology
- 1 December 1995
Observations define a cell type-specific, transcription factor signaling pathway necessary for SV- induced apoptosis, and the precise mechanism by which Bcl-2 and thiol agents inhibit SV-induced nuclear NF-kappa B activity in AT-3 cells may provide insights into the pluripotent antiapoptotic actions of these agents.