EGLN1 gene

Known as: EGL9, C. ELEGANS, HOMOLOG OF, 1, PHD2, HYPOXIA-INDUCIBLE FACTOR PROLYL 4-HYDROXYLASE 2 
This gene plays a role in both protein modification and oxygen homeostasis.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Tibetans do not exhibit increased hemoglobin concentration at high altitude. We describe a high-frequency missense mutation in… (More)
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Highly Cited
2010
Highly Cited
2010
Tibetans have lived at very high altitudes for thousands of years, and they have a distinctive suite of physiological traits that… (More)
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Highly Cited
2010
Highly Cited
2010
High-altitude hypoxia (reduced inspired oxygen tension due to decreased barometric pressure) exerts severe physiological stress… (More)
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Highly Cited
2010
Highly Cited
2010
It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility… (More)
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Highly Cited
2005
Highly Cited
2005
Low oxygen levels induce an adaptive response in cells through the activation of HIFs (hypoxia-inducible factors). These… (More)
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2005
2005
The cellular response to hypoxia is, at least in part, mediated by the transcriptional regulation of hypoxia-responsive genes… (More)
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Highly Cited
2004
Highly Cited
2004
Covalent modification of histones is important in regulating chromatin dynamics and transcription. One example of such… (More)
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Highly Cited
2003
Highly Cited
2003
Most of the genes induced by hypoxia are regulated by a family of transcription factors termed hypoxia-inducible factors (HIF… (More)
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Highly Cited
2001
Highly Cited
2001
Rat Sm-20 is a homologue of the Caenorhabditis elegans gene egl-9 and has been implicated in the regulation of growth… (More)
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Highly Cited
1997
Highly Cited
1997
In Drosophila melanogaster, the Polycomb-group (PcG) genes have been identified as repressors of gene expression. They are part… (More)
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