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EGLN1 gene

Known as: EGL9, C. ELEGANS, HOMOLOG OF, 1, PHD2, HYPOXIA-INDUCIBLE FACTOR PROLYL 4-HYDROXYLASE 2 
This gene plays a role in both protein modification and oxygen homeostasis.
National Institutes of Health

Related topics

Related topics

5 relations
EGLN1 protein, humanEgl Nine Homolog 1HomeostasisOxidation-Reduction

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EGLN1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection
Highly Cited
2014
Highly Cited
2014
A genetic mechanism for Tibetan high-altitude adaptation
Tibetans do not exhibit increased hemoglobin concentration at high altitude. We describe a high-frequency missense mutation in… 
Highly Cited
2010
Highly Cited
2010
EGLN1 involvement in high-altitude adaptation revealed through genetic analysis of extreme constitution types defined in Ayurveda
It is being realized that identification of subgroups within normal controls corresponding to contrasting disease susceptibility… 
Highly Cited
2010
Highly Cited
2010
Genes for High Altitudes
Analyses of genomes from Tibetan populations reveal a signaling pathway that may account for high-altitude adaptation. During the… 
Highly Cited
2007
Highly Cited
2007
The new tumor-suppressor gene inhibitor of growth family member 4 (ING4) regulates the production of proangiogenic molecules by myeloma cells and suppresses hypoxia-inducible factor-1 alpha (HIF…
Angiogenesis has a critical role in the pathophysiology of multiple myeloma (MM); however, the molecular mechanisms underlying… 
Highly Cited
2007
Highly Cited
2007
Succinate inhibition of α-ketoglutarate-dependent enzymes in a yeast model of paraganglioma
The tricarboxylic acid (TCA) cycle enzyme succinate dehydrogenase (SDH) is a tumor suppressor. Heterozygosity for defective SDH… 
Highly Cited
2006
Highly Cited
2006
The Polybasic Region That Follows the Plant Homeodomain Zinc Finger 1 of Pf1 Is Necessary and Sufficient for Specific Phosphoinositide Binding*
The plant homeodomain (PHD) zinc finger is one of 14 known zinc-binding domains. PHD domains have been found in more than 400… 
Highly Cited
2004
Highly Cited
2004
A mixed culture of Propionibacterium jensenii and Lactobacillus paracasei subsp. paracasei inhibits food spoilage yeasts.
Screening for antimicrobial features of 197 propionibacteria and tests with several antifungal lactobacilli led to the… 
Highly Cited
2004
Highly Cited
2004
Hph1p and Hph2p, Novel Components of Calcineurin-Mediated Stress Responses in Saccharomyces cerevisiae
ABSTRACT Calcineurin is a Ca2+- and calmodulin-dependent protein phosphatase that plays a key role in animal and yeast physiology… 
Highly Cited
2001
Highly Cited
2001
Characterization and comparative analysis of the EGLN gene family.
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