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EGLN1 gene

Known as: EGL9, C. ELEGANS, HOMOLOG OF, 1, PHD2, HYPOXIA-INDUCIBLE FACTOR PROLYL 4-HYDROXYLASE 2 
This gene plays a role in both protein modification and oxygen homeostasis.
National Institutes of Health

Related topics

Related topics

5 relations
EGLN1 protein, humanEgl Nine Homolog 1HomeostasisOxidation-Reduction

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EGLN1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
PTEN induces apoptosis and cavitation via HIF-2-dependent Bnip3 upregulation during epithelial lumen formation
The tumor suppressor phosphatase and tensin homolog (PTEN) dephosphorylates PIP3 and antagonizes the prosurvival PI3K-Akt pathway… 
Highly Cited
2006
Highly Cited
2006
The Polybasic Region That Follows the Plant Homeodomain Zinc Finger 1 of Pf1 Is Necessary and Sufficient for Specific Phosphoinositide Binding*
The plant homeodomain (PHD) zinc finger is one of 14 known zinc-binding domains. PHD domains have been found in more than 400… 
Highly Cited
2006
Highly Cited
2006
A novel series of imidazo[1,2-a]pyridine derivatives as HIF-1alpha prolyl hydroxylase inhibitors.
Highly Cited
2005
Highly Cited
2005
Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1.
The cellular response to hypoxia is, at least in part, mediated by the transcriptional regulation of hypoxia-responsive genes… 
2004
2004
P66ShcA interacts with MAPKAP kinase 2 and regulates its activity
2003
2003
Induction of SM‐20 in PC12 cells leads to increased cytochrome c levels, accumulation of cytochrome c in the cytosol, and caspase‐dependent cell death
Sympathetic neurons deprived of nerve growth factor (NGF) release cytochrome c into the cytosol and undergo caspase‐dependent… 
2000
2000
Mapping, characterization, and expression analysis of the SM-20 human homologue, c1orf12, and identification of a novel related gene, SCAND2.
Major psychosis was shown to segregate with a balanced translocation (1q42.1; 11q14.3) in a multigenerational family. This study… 
1999
1999
SM-20 is a novel growth factor-responsive gene regulated during skeletal muscle development and differentiation.
SM-20 is a novel, evolutionarily conserved "early response" gene originally cloned from a rat aortic smooth muscle cell (SMC… 
1996
1996
SM-20 is a novel 40-kd protein whose expression in the arterial wall is restricted to smooth muscle.
We have previously reported the identification of a novel cDNA, SM-20, whose corresponding mRNA levels are regulated by growth… 
1990
1990
Characterisation of Sm20, a 20-kilodalton calcium-binding protein of Schistosoma mansoni.
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