Egl Nine Homolog 1

Known as: Hypoxia-Inducible Factor Prolyl Hydroxylase 2, HIF-PH2, Prolyl Hydroxylase Domain-Containing Protein 2 
Egl nine homolog 1 (426 aa, ~46 kDa) is encoded by the human EGLN1 gene. This protein plays a role in the modification of hypoxia-inducible factor… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1991-2017
0246819912017

Papers overview

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2011
2011
Mammalian cells express dozens of iron-containing proteins, yet little is known about the mechanism of metal ligand incorporation… (More)
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Highly Cited
2008
Highly Cited
2008
Pharmacologic activation of the heterodimeric HIF transcription factor appears promising as a strategy to treat diseases, such as… (More)
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2008
2008
BACKGROUND AND PURPOSE Hypoxia-inducible factor (HIF) is a transcription factor induced by hypoxia and degraded by ubiquitin… (More)
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2007
Highly Cited
2007
The activity and levels of the metazoan HIF (hypoxia-inducible factor) are regulated by its hydroxylation, catalysed by 2OG (2… (More)
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Highly Cited
2006
Highly Cited
2006
Cellular and physiological responses to changes in dioxygen levels in metazoans are mediated via the posttranslational oxidation… (More)
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Highly Cited
2005
Highly Cited
2005
The HIFs (hypoxia-inducible factors) are a family of heterodimeric transcription factors essential for the adaptation of cells to… (More)
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2004
2004
Adaptations to change in oxygen availability are crucial for survival of multi-cellular organisms and are also implicated in… (More)
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2003
2003
Sympathetic neurons deprived of nerve growth factor (NGF) release cytochrome c into the cytosol and undergo caspase-dependent… (More)
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2001
2001
Rat Sm-20 is a homologue of the Caenorhabditis elegans gene egl-9 and has been implicated in the regulation of growth… (More)
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2001
2001
Sympathetic neurons undergo protein synthesis-dependent apoptosis when deprived of nerve growth factor (NGF). Expression of SM-20… (More)
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