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EF1502

Known as: EF 1502 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Isoxazoles

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function
2014
2014
The Subcellular Localization of GABA Transporters and Its Implication for Seizure Management
The ability to modulate the synaptic GABA levels has been demonstrated by using the clinically effective and selective GAT1… 
Highly Cited
2011
Highly Cited
2011
Deletion of the betaine–GABA transporter (BGT1; slc6a12) gene does not affect seizure thresholds of adult mice
Highly Cited
2011
Highly Cited
2011
Selective GABA Transporter Inhibitors Tiagabine and EF1502 Exhibit Mechanistic Differences in Their Ability to Modulate the Ataxia and Anticonvulsant Action of the Extrasynaptic GABAA Receptor…
Modulation of the extracellular levels of GABA via inhibition of the synaptic GABA transporter GAT1 by the clinically effective… 
Highly Cited
2009
Highly Cited
2009
Synaptic and extrasynaptic GABA transporters as targets for anti‐epileptic drugs
Inhibition of the GABA transporter subtype GAT1 by the clinically available anti‐epileptic drug tiagabine has proven to be an… 
2008
2008
Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC)
Review
2006
Review
2006
A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS
Highly Cited
2005
Highly Cited
2005
First Demonstration of a Functional Role for Central Nervous System Betaine/γ-Aminobutyric Acid Transporter (mGAT2) Based on Synergistic Anticonvulsant Action among Inhibitors of mGAT1 and mGAT2
In a recent study, EF1502 [N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]-3-hydroxy-4-(methylamino)-4,5,6,7-tetrahydrobenzo [d… 
Review
2004
Review
2004
GABA transporters as drug targets for modulation of GABAergic activity.
Review
2004
Review
2004
Role of the betaine/GABA transporter (BGT-1/GAT2) for the control of epilepsy.
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