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EB 1089

Known as: EB-1089, EB1089 
National Institutes of Health

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1 relation

Broader (1)

seocalcitol

Papers overview

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Highly Cited
2006
Highly Cited
2006
Potentiation of radiation sensitivity in breast tumor cells by the vitamin D3 analogue, EB 1089, through promotion of autophagy and interference with proliferative recovery
1,25-Dihydroxyvitamin D3 and vitamin D3 analogues, such as EB 1089, potentiate the response to ionizing radiation in breast tumor… 
Highly Cited
2003
Highly Cited
2003
Inhibition of F-Box protein p45(SKP2) expression and stabilization of cyclin-dependent kinase inhibitor p27(KIP1) in vitamin D analog-treated cancer cells.
Treatment of cancer cells with 1,25-dihydroxyvitamin D3 [1,25(OH)(2)D(3)] or its analogs induces growth arrest and expression of… 
Highly Cited
2003
Highly Cited
2003
Characterization of mammary tumor cell lines from wild type and vitamin D3 receptor knockout mice
2003
2003
Effects of Seocalcitol (EB1089) on Nitrosomethyl Urea-Induced Rat Mammary Tumors
Although 1,25-dihydroxyvitamin D3 is a potent cell-differentiating agent, its use in cancer prevention or therapy is precluded… 
Highly Cited
2002
Highly Cited
2002
Vitamin D receptor‐dependent antitumour effects of 1,25‐dihydroxyvitamin D3 and two synthetic analogues in three in vivo models of prostate cancer
Objective  To determine the in vitro and in vivo effects of 1,25‐dihydroxyvitamin D 3 (calcitriol) and two newer less… 
2002
2002
Vitamin D and Its Analog EB1089 Induce p27 Accumulation and Diminish Association of p27 with Skp2 Independent of PTEN in Pituitary Corticotroph Cells
Disruption of the gene for the cyclin dependent kinase inhibitor (CDKI) p27/kip1 results in pituitary corticotroph hyperplasia… 
2001
2001
Anti-oestrogen resistant human breast cancer cell lines are more sensitive towards treatment with the vitamin D analogue EB1089 than parent MCF-7 cells
Most breast cancer patients treated with anti-oestrogens will eventually develop resistance towards treatment. Therefore it is… 
1999
1999
Potentiation by vitamin D analogs of TNFα and ceramide-induced apoptosis in MCF-7 cells is associated with activation of cytosolic phospholipase A2
Synthetic analogs of vitamin D induce apoptosis in cultured breast cancer cells and cause regression of experimentally-induced… 
Highly Cited
1997
Highly Cited
1997
Vitamin D3 analog, EB1089, inhibits growth of subcutaneous xenografts of the human colon cancer cell line, LoVo, in a nude mouse model
PURPOSE: In this study, we investigated the effect of the vitamin D3analog, EB1089, on the growth of subcutaneous xenografts of… 
Highly Cited
1994
Highly Cited
1994
All-trans retinoic acid and 1 alpha,25-dihydroxyvitamin D3 co-operate to promote differentiation of the human promyeloid leukemia cell line HL60 to monocytes.
A basis for differentiation therapy of leukemias is provided by knowledge of agents which induce specific lineage maturation. All… 
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