FAQ

E3 SUMO-protein ligase CBX4

Known as: hPc2, Chromobox Protein Homolog 4, Pc2 
E3 SUMO-protein ligase CBX4 (558 aa, ~61 kDa) is encoded by the human CBX4 gene. This soluble, nuclear protein plays a role in repressing the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2018
0519872018

Related topics

Related topics

10 relations
CBX4 geneCBX4 wt AlleleChromatin Remodeling FactorGene Silencing Pathway
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Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
E3 SUMO-protein ligase CBX4
Transcriptional Regulation
Transcription Repressor/Corepressor
Genes, Regulator
Homo sapiens
Transcriptional Repression

Papers overview

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2014
2014
A principal component analysis of postinjury viscoelastic assays: clotting factor depletion versus fibrinolysis.
INTRODUCTION The mechanisms driving trauma-induced coagulopathy (TIC) remain to be defined, and its therapy demands an… (More)
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2007
2007
Quality assessment of cortex cinnamomi by HPLC chemical fingerprint, principle component analysis and cluster analysis.
HPLC fingerprint analysis, principle component analysis (PCA), and cluster analysis were introduced for quality assessment of… (More)
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Highly Cited
2002
Highly Cited
2002
Severe block in processing of proinsulin to insulin accompanied by elevation of des-64,65 proinsulin intermediates in islets of mice lacking prohormone convertase 1/3.
The neuroendocrine processing endoproteases PC2 and PC1/3 are expressed in the beta cells of the islets of Langerhans and… (More)
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2001
2001
IDA-1, a Caenorhabditis elegans homolog of the diabetic autoantigens IA-2 and phogrin, is expressed in peptidergic neurons in the worm.
The closely related mammalian proteins IA-2 and phogrin are protein tyrosine phosphatase-like receptor proteins spanning the… (More)
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Highly Cited
1999
Highly Cited
1999
Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation
Polycomb-group (PcG) proteins form multimeric protein complexes, which are involved in maintaining the transcriptional repressive… (More)
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1995
1995
Electron microscopic immunocytochemical evidence for the involvement of the convertases PC1 and PC2 in the processing of proinsulin in pancreatic beta-cells.
Endoproteolytic cleavage of pairs of basic amino acids is the key mechanism in the specific processing of precursor hormone… (More)
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1995
1995
7B2 is a specific intracellular binding protein of the prohormone convertase PC2.
Biosynthetic pulse-chase analyses have previously demonstrated that the prohormone convertase PC2 is first synthesized as a… (More)
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1993
1993
The biosynthesis of the subtilisin-related proprotein convertase PC3, but no that of the PC2 convertase, is regulated by glucose in parallel to proinsulin biosynthesis in rat pancreatic islets.
The biosynthesis of proinsulin is specifically stimulated by glucose in the pancreatic beta-cell, and this, in turn, places an… (More)
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1992
1992
Identification of the type 2 proinsulin processing endopeptidase as PC2, a member of the eukaryote subtilisin family.
Enzymological studies have implicated two Ca(2+)-dependent endopeptidases in the conversion of proinsulin to insulin; a type 1… (More)
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Highly Cited
1990
Highly Cited
1990
Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex2.
We have identified a human insulinoma cDNA (PC2) that encodes a protein homologous to the precursor processing Kex2 endoprotease… (More)
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