E3 SUMO-protein ligase CBX4

Known as: hPc2, Chromobox Protein Homolog 4, Pc2 
E3 SUMO-protein ligase CBX4 (558 aa, ~61 kDa) is encoded by the human CBX4 gene. This soluble, nuclear protein plays a role in repressing the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2018
0519872018

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2014
2014
INTRODUCTION The mechanisms driving trauma-induced coagulopathy (TIC) remain to be defined, and its therapy demands an… (More)
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2007
2007
HPLC fingerprint analysis, principle component analysis (PCA), and cluster analysis were introduced for quality assessment of… (More)
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Highly Cited
2002
Highly Cited
2002
The neuroendocrine processing endoproteases PC2 and PC1/3 are expressed in the beta cells of the islets of Langerhans and… (More)
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2001
2001
The closely related mammalian proteins IA-2 and phogrin are protein tyrosine phosphatase-like receptor proteins spanning the… (More)
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1999
Highly Cited
1999
Polycomb-group (PcG) proteins form multimeric protein complexes, which are involved in maintaining the transcriptional repressive… (More)
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1995
1995
Endoproteolytic cleavage of pairs of basic amino acids is the key mechanism in the specific processing of precursor hormone… (More)
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1995
1995
Biosynthetic pulse-chase analyses have previously demonstrated that the prohormone convertase PC2 is first synthesized as a… (More)
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1993
1993
The biosynthesis of proinsulin is specifically stimulated by glucose in the pancreatic beta-cell, and this, in turn, places an… (More)
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1992
1992
Enzymological studies have implicated two Ca(2+)-dependent endopeptidases in the conversion of proinsulin to insulin; a type 1… (More)
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Highly Cited
1990
Highly Cited
1990
We have identified a human insulinoma cDNA (PC2) that encodes a protein homologous to the precursor processing Kex2 endoprotease… (More)
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