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E3 SUMO-protein ligase CBX4

Known as: hPc2, Chromobox Protein Homolog 4, Pc2 
E3 SUMO-protein ligase CBX4 (558 aa, ~61 kDa) is encoded by the human CBX4 gene. This soluble, nuclear protein plays a role in repressing the… Expand
National Institutes of Health

Related topics

Related topics

10 relations
CBX4 geneCBX4 wt AlleleChromatin Remodeling FactorGene Silencing Pathway
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase.
The histone lysine demethylase KDM5B plays key roles in gene repression by demethylating trimethylated lysine 4 of histone H3… Expand
Is this relevant?
2009
2009
SUMO-dependent regulation of centrin-2.
Centrins are multifunctional Ca(2+)-binding proteins that are highly conserved from yeast to humans. Centrin-2 is a core… Expand
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Highly Cited
2008
Highly Cited
2008
Role of the PLDLS-binding cleft region of CtBP1 in recruitment of core and auxiliary components of the corepressor complex.
C-terminal binding protein (CtBP) family proteins CtBP1 and CtBP2 are highly homologous transcriptional corepressors and are… Expand
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Review
2007
Review
2007
Transcriptional regulation by C-terminal binding proteins.
  • G. Chinnadurai
  • The international journal of biochemistry & cell…
  • 2007
    • Corpus ID: 3158104
C-terminal binding protein family members function predominantly as transcriptional corepressors in association with sequence… Expand
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Highly Cited
2003
Highly Cited
2003
Poorly differentiated breast carcinoma is associated with increased expression of the human polycomb group EZH2 gene.
Polycomb group (PcG) genes contribute to the maintenance of cell identity, cell cycle regulation, and oncogenesis. We describe… Expand
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2002
2002
Selective interactions between vertebrate polycomb homologs and the SUV39H1 histone lysine methyltransferase suggest that histone H3-K9 methylation contributes to chromosomal targeting of Polycomb…
Polycomb group (PcG) proteins form multimeric chromatin-associated protein complexes that are involved in heritable repression of… Expand
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2002
2002
A panel of monoclonal antibodies against human polycomb group proteins.
Polycomb-group (PcG) proteins are chromatin-associated proteins that heritably repress gene activity in many organisms, including… Expand
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Highly Cited
1999
Highly Cited
1999
RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity.
Polycomb-group (PcG) proteins form large multimeric protein complexes that are involved in maintaining the transcriptionally… Expand
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Highly Cited
1998
Highly Cited
1998
Characterization of interactions between the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes.
In Drosophila melanogaster, the Polycomb-group (PcG) and trithorax-group (trxG) genes have been identified as repressors and… Expand
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Highly Cited
1997
Highly Cited
1997
Interference with the expression of a novel human polycomb protein, hPc2, results in cellular transformation and apoptosis.
Polycomb (Pc) is involved in the stable and heritable repression of homeotic gene activity during Drosophila development. Here… Expand
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