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Bell-shaped calcium-response curves of lns(l,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum
RELEASE of calcium from intracellular stores occurs by two pathways, an inositol 1,4,5-trisphosphate (InsP3)-gated channel1–3 and a calcium-gated channel (ryanodine receptor)4–6. Using specificExpand
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Polycystin-2 is an intracellular calcium release channel
Polycystin-2, the product of the gene mutated in type 2 autosomal dominant polycystic kidney disease (ADPKD), is the prototypical member of a subfamily of the transient receptor potential (TRP)Expand
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The pharmacology of intracellular Ca2+-release channels
Abstract Two classes of intracellular Ca 2+ -release channels, the ryanodine reccptor and the mositol (1,4,5)-trisphosphate (IP 3 ) receptor, are essential for spatiotemporal Ca 2+ signalling inExpand
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Inositol (1,4,5)-trisphosphate (InsP3)-gated Ca channels from cerebellum: conduction properties for divalent cations and regulation by intraluminal calcium
The conduction properties of inositol (1,4,5)-trisphosphate (InsP3)- gated calcium (Ca) channels (InsP3R) from canine cerebellum for divalent cations and the regulation of the channels byExpand
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Type III InsP3 receptor channel stays open in the presence of increased calcium
The inositol 1,4,5-trisphosphate receptor (InsP3R) is the main calcium(Ca2+) release channel in most tissues. Three isoforms have been identified, but only types I and II InsP3R have beenExpand
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The pharmacology of intracellular Ca(2+)-release channels.
Two classes of intracellular Ca(2+)-release channels, the ryanodine receptor and the inositol (1,4,5)-trisphosphate (IP3) receptor, are essential for spatio-temporal Ca2+ signalling in cells. HeparinExpand
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Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd2
Distinguishing Right from Left In most vertebrates during embryonic development, rotational movement of the cilia within a structure in the embryo, known as the node, generates unidirectional flowExpand
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Inositol 1,4,5-Trisphosphate (InsP3) and Calcium Interact to Increase the Dynamic Range of InsP3 Receptor-dependent Calcium Signaling
The inositol 1,4,5-trisphosphate (InsP3)-gated Ca channel in cerebellum is tightly regulated by Ca (Bezprozvanny, I., J. Watras, and B.E. Ehrlich. 1991. Nature (Lond.). 351:751–754; Finch, E.A., T.J.Expand
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ATP modulates the function of inositol 1,4,5-trisphosphate-gated channels at two sites
The inositol 1,4,5-trisphosphate (IP3) receptor, a Ca(2+)-permeable channel, plays a key role in intracellular Ca2+ signaling. The effects of ATP on the IP3 receptor at the single-channel level wereExpand
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