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E2F1 gene

Known as: E2F Transcription Factor 1 Gene, RBP3, E2F TRANSCRIPTION FACTOR 1 
This gene plays a regulatory role in G1/S cell cycle checkpoints and apoptosis.
National Institutes of Health

Related topics

Related topics

13 relations
ARID4A geneApoptosisE2F transcription factorsE2F1 Transcription Factor

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E2F1 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
CTSL2 is a pro-apoptotic target of E2F1 and a modulator of histone deacetylase inhibitor and DNA damage-induced apoptosis
Aberrant regulation of the pRB/E2F1 pathway has been invariably linked to inappropriate proliferation and/apoptosis in human… 
2010
2010
RB-E2F1
The retinoblastoma protein (RB) is the product encoded by the first tumor suppressor gene identified, and exerts a pleitropic… 
2010
2010
Transcription factor E2F1 is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene.
2010
2010
e2f1 Gene is a new member of Wnt/beta-catenin/Tcf-regulated genes.
2009
2009
Knockdown of E2f1 by RNA interference impairs proliferation of rat cells in vitro
E2F1 plays a key role in cell-cycle regulation in mammals, since its transcription factor activity controls genes required for… 
Highly Cited
2003
Highly Cited
2003
Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice
The E2f1 transcription factor, which regulates genes required for S-phase entry, also induces apoptosis by transcriptional and… 
Highly Cited
2002
Highly Cited
2002
ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc
ABSTRACT The ARF tumor suppressor participates in a p53-dependent apoptotic pathway that is stimulated in response to some… 
2002
2002
Differences in DNA binding properties between E2F1 and E2F4 specify repression of the Mcl-1 promoter
E2F1 is a potent inducer of apoptosis whereas its relative, E2F4, generally does not promote cell death. Other work from our… 
Highly Cited
2000
Highly Cited
2000
E2F4 and E2F1 Have Similar Proliferative Properties but Different Apoptotic and Oncogenic Properties In Vivo
ABSTRACT Loss of retinoblastoma (Rb) tumor suppressor function, as occurs in many cancers, leads to uncontrolled proliferation… 
1995
1995
Thirteen genes (Cebpb, E2f1, Tcf4, Cyp24, Pck1, Acra4, Edn3, Kcnb1, Mc3r, Ntsr, Cd40, Plcg1 and Rcad) that probably lie in the distal imprinting region of mouse chromosome 2 are not monoallelically…
Seven imprinted genes are currently known in the mouse but none have been identified yet in the distal imprinting region of mouse… 
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