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E2F1 gene

Known as: E2F Transcription Factor 1 Gene, RBP3, E2F TRANSCRIPTION FACTOR 1 
This gene plays a regulatory role in G1/S cell cycle checkpoints and apoptosis.
National Institutes of Health

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Related topics

13 relations
ARID4A geneApoptosisE2F transcription factorsE2F1 Transcription Factor

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E2F1 wt Allele

Papers overview

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Highly Cited
2016
Highly Cited
2016
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis.
E2F transcription factors are known regulators of the cell cycle, proliferation, apoptosis, and differentiation. Here, we reveal… 
Highly Cited
2010
Highly Cited
2010
E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosis
E2F1 is a positive regulator of cell cycle progression and also a potent inducer of apoptosis, especially when activated by DNA… 
Highly Cited
2010
Highly Cited
2010
miR‐149* induces apoptosis by inhibiting Akt1 and E2F1 in human cancer cells
microRNAs (miRNAs) play vital roles in several biological processes, including apoptosis, by negatively regulating the expression… 
Highly Cited
2009
Highly Cited
2009
E2F1-3 Switch from Activators in Progenitor Cells to Repressors in Differentiating Cells
In the established model of mammalian cell cycle control, the retinoblastoma protein (Rb) functions to restrict cells from… 
Highly Cited
2008
Highly Cited
2008
Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase.
Highly Cited
2006
Highly Cited
2006
Jab1 is a specificity factor for E2F1-induced apoptosis.
The members of the E2F family of transcription factors are key regulators of genes involved in cell cycle progression, cell fate… 
Highly Cited
2004
Highly Cited
2004
Apoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2
ABSTRACT The retinoblastoma protein (Rb)/E2F pathway links cellular proliferation control to apoptosis and is critical for normal… 
Highly Cited
2003
Highly Cited
2003
Inactivating E2f1 reverts apoptosis resistance and cancer sensitivity in Trp53-deficient mice
The E2f1 transcription factor, which regulates genes required for S-phase entry, also induces apoptosis by transcriptional and… 
Highly Cited
2002
Highly Cited
2002
ARF Differentially Modulates Apoptosis Induced by E2F1 and Myc
ABSTRACT The ARF tumor suppressor participates in a p53-dependent apoptotic pathway that is stimulated in response to some… 
Highly Cited
2000
Highly Cited
2000
E2F4 and E2F1 Have Similar Proliferative Properties but Different Apoptotic and Oncogenic Properties In Vivo
ABSTRACT Loss of retinoblastoma (Rb) tumor suppressor function, as occurs in many cancers, leads to uncontrolled proliferation… 
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