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E 4021

Known as: E-4021, E4021 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (4)

Phosphodiesterase InhibitorsPiperidinesPlatelet Aggregation InhibitorsQuinazolines

Papers overview

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2005
2005
Selective type 5 phosphodiesterase inhibition alters pulmonary hemodynamics and lung liquid production in near-term fetal lambs.
Nitric oxide causes dilation of the pulmonary circulation and reduction in net lung liquid production in the fetal lamb, two… 
2004
2004
Differential inhibitor sensitivity between human recombinant and native photoreceptor cGMP-phosphodiesterases (PDE6s).
2003
2003
Endothelial responses of the aorta from adrenomedullin transgenic mice and knockout mice.
Adrenomedullin (AM) is a potent vascular wall-derived vasorelaxing peptide which induces the release of nitric oxide (NO). To… 
2001
2001
Phosphodiesterase 5 inhibition restores impaired ACh relaxation in hypertensive conduit pulmonary arteries.
  • M. Oka
  • American Journal of Physiology - Lung cellular…
  • 2001
  • Corpus ID: 36666886
Responses to acetylcholine (ACh) and sodium nitroprusside (SNP) were compared in large (LPA) and small pulmonary artery (SPA… 
2000
2000
Functional identification of phosphodiesterase activity in human trabecular meshwork cells.
The phosphodiesterases (PDE) activity in human trabecular meshwork cells (HTM-3) was investigated in this study in order to… 
2000
2000
E4021, a selective phosphodiesterase 5 inhibitor, potentiates the vasodilateor effect of inhaled nitric oxide in isolated perfused rat lungs
1999
1999
E4021, a selective phosphodiesterase 5 inhibitor, potentiates the vasodilator effect of inhaled nitric oxide in isolated perfused rat lungs.
To test whether E4021, a potent selective cyclic guanosine 3'-5'-monophosphate (cGMP) phosphodiesterase inhibitor, causes… 
1997
1997
Type V phosphodiesterase inhibition modulates endogenous immunoreactivities of endothelin-1 and endothelial nitric oxide synthase in pulmonary arteries in rats with monocrotaline-induced pulmonary…
We evaluated the effects of oral administration of E4021 (100 mg/ kg/day), a type V phosphodiesterase inhibitor, on… 
1994
1994
Effects of a novel, selective and potent phosphodiesterase type V inhibitor, E4021, on myocardial ischemia in guinea pigs.
1994
1994
CARDIOHEMODYNAMIC EFFECTS OF A NOVEL SELECTIVE AND POTENT PHOSPHODIESTERASE V INHIBITOR, E4021, IN THE PIG
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