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E 4021
Known as:
E-4021
, E4021
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (4)
Phosphodiesterase Inhibitors
Piperidines
Platelet Aggregation Inhibitors
Quinazolines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2001
2001
Effects of intracavernous administration of adrenomedullin on erectile function in rats
H. Nishimatsu
,
Y. Hirata
,
+11 authors
T. Kitamura
Peptides
2001
Corpus ID: 24340813
Highly Cited
1999
Highly Cited
1999
Role of nitric oxide-cGMP pathway in adrenomedullin-induced vasodilation in the rat.
H. Hayakawa
,
Y. Hirata
,
+10 authors
M. Omata
HYPERTENSION
1999
Corpus ID: 6411106
We previously reported that adrenomedullin (AM), a potent vasodilator peptide discovered in pheochromocytoma cells, stimulates…
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1999
1999
Potency and mechanism of action of E4021, a type 5 phosphodiesterase isozyme-selective inhibitor, on the photoreceptor phosphodiesterase depend on the state of activation of the enzyme.
M. D'Amours
,
A. Granovsky
,
N. Artemyev
,
R. Cote
Molecular Pharmacology
1999
Corpus ID: 11346565
The ability of inhibitors selective for the type 5 phosphodiesterase isozyme (PDE5) to act on the photoreceptor PDE isozyme (PDE6…
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1999
1999
Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells.
Ling Zhou
,
William J. Thompson
,
David E. Potter
Investigative Ophthalmology and Visual Science
1999
Corpus ID: 12763132
PURPOSE To characterize cyclic nucleotide phosphodiesterase isozyme activities in human trabecular meshwork cells and primary…
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Highly Cited
1998
Highly Cited
1998
4-Benzylamino-1-chloro-6-substituted phthalazines: synthesis and inhibitory activity toward phosphodiesterase 5.
N. Watanabe
,
Y. Kabasawa
,
+5 authors
H. Adachi
Journal of Medicinal Chemistry
1998
Corpus ID: 39063512
We synthesized various 4-benzylamino-1-chloro-6-substituted phthalazines (15) and 4-benzylamino-1-chloro-7-substituted…
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Highly Cited
1996
Highly Cited
1996
Antiplatelet and antiproliferative effects of SCH 51866, a novel type 1 and type 5 phosphodiesterase inhibitor.
S. Vemulapalli
,
R. Watkins
,
+8 authors
E. Sybertz
Journal of Cardiovascular Pharmacology
1996
Corpus ID: 19785493
SCH 51866 is a potent and selective PDE1 and PDE5 inhibitor. The antiplatelet, antiproliferative, and hemodynamic effects of SCH…
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1996
1996
Characterization of the isoenzymes of cyclic nucleotide phosphodiesterase in human platelets and the effects of E4021.
M. Ito
,
M. Nishikawa
,
+4 authors
T. Nakano
Cellular Signalling
1996
Corpus ID: 21547464
1996
1996
A selective type V phosphodiesterase inhibitor, E4021, protects the development of right ventricular overload and medial thickening of pulmonary arteries in a rat model of pulmonary hypertension.
Takashi Takahashi
,
T. Kanda
,
+4 authors
R. Nagai
Life Science
1996
Corpus ID: 21843407
Highly Cited
1995
Highly Cited
1995
A selective type V phosphodiesterase inhibitor, E4021, dilates porcine large coronary artery.
T. Saeki
,
H. Adachi
,
Y. Takase
,
S. Yoshitake
,
S. Souda
,
I. Saito
Journal of Pharmacology and Experimental…
1995
Corpus ID: 10903947
We investigated the inhibitory effects of a newly synthesized compound, sodium 1-[6-chloro-4-(3,4-methylenedioxybenzyl…
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1995
1995
Isoenzymes of cyclic nucleotide phosphodiesterase in the human aorta: characterization and the effects of E4021.
M. Miyahara
,
M. Ito
,
+4 authors
T. Nakano
European Journal of Pharmacology
1995
Corpus ID: 4620647
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