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Disintegrins

Known as: Disintegrins [Chemical/Ingredient] 
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to… 
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (21)

DisBa-01, Bothrops alternatusEMF10 protein, Eristocophis macmahoniaccutinacostatin
In BloodProcess of secretionagonistsantagonists & inhibitors

Broader (2)

PeptidesPlatelet Aggregation Inhibitors

Papers overview

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2009
2009
Echistatin: the refined structure of a disintegrin in solution by 1H NMR and restrained molecular dynamics.
The structure of the disintegrin echistatin has been determined by 1H NMR, distance geometry calculations and restrained… 
Review
2005
Review
2005
Snake venom probes of platelet adhesion receptors and their ligands.
2003
2003
Disintegrin causes proteolysis of beta-catenin and apoptosis of endothelial cells. Involvement of cell-cell and cell-ECM interactions in regulating cell viability.
Disintegrins, the snake venom-derived arginine-glycine-aspartic acid-containing peptides, have been demonstrated to inhibit… 
2000
2000
Purification, cloning and sequence analyses for pro-metalloprotease-disintegrin variants from Deinagkistrodon acutus venom and subclassification of the small venom metalloproteases.
Acidic and basic hemorrhagic metalloproteases were purified from the venom of Deinagkistrodon acutus (from Fujian Province, China… 
1996
1996
Inhibition of retinal pigment epithelial cell-induced tractional retinal detachment by disintegrins, a group of Arg-Gly-Asp-containing peptides from viper venom.
PURPOSE Integrin-mediated extracellular matrix (ECM) attachment plays an important role in vitreous contraction of retinal… 
1996
1996
Comparison of iodine-123-disintegrins for imaging thrombi and emboli in a canine model.
UNLABELLED Disintegrins are peptides found in viper venoms which bind to platelets through the glycoprotein IIb-IIIa receptor… 
Highly Cited
1994
Highly Cited
1994
Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation.
Tyrosine phosphorylation of multiple platelet proteins is regulated by the integrin alpha IIb beta 3. In order to further examine… 
1994
1994
Analysis of Human Platelet Glycoprotein llb-llla by Fluorescein Isothiocyanate-Conjugated Disintegrins with Flow Cytometry
Summary Disintegrins are a group of snake venom peptides which inhibit human platelet aggregation by acting as glycoprotein Ilb… 
Review
1992
Review
1992
Disintegrins: RGD-containing proteins which inhibit cell/matrix interactions (adhesion) and cell/cell interactions (aggregation) via the integrin receptors.
Whereas many attempts have been made to generate synthetic, high affinity, linear RGD-peptides (Arginine-Glycine-Aspartic acid… 
Review
1992
Review
1992
Structure, function and evolutionary relationship of proteins containing a disintegrin domain
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