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Disintegrins

Known as: Disintegrins [Chemical/Ingredient] 
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to… 
National Institutes of Health

Related topics

Related topics

31 relations

Narrower (21)

DisBa-01, Bothrops alternatusEMF10 protein, Eristocophis macmahoniaccutinacostatin
In BloodProcess of secretionagonistsantagonists & inhibitors

Broader (2)

PeptidesPlatelet Aggregation Inhibitors

Papers overview

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Highly Cited
2008
Highly Cited
2008
Evolution of snake venom disintegrins by positive Darwinian selection.
PII-disintegrins, cysteine-rich polypeptides broadly distributed in the venoms of geographically diverse species of vipers and… 
Highly Cited
2006
Highly Cited
2006
Metalloproteinase Disintegrins ADAM8 and ADAM19 Are Highly Regulated in Human Primary Brain Tumors and their Expression Levels and Activities Are Associated with Invasiveness
Patients with primary brain tumors have bleak prognoses and there is an urgent desire to identify new markers for sensitive… 
Review
2005
Review
2005
Shedding light on ADAM metalloproteinases.
Review
2005
Review
2005
Snake venom disintegrins: evolution of structure and function.
Highly Cited
2003
Highly Cited
2003
Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering.
We report the isolation and amino acid sequences of six novel dimeric disintegrins from the venoms of Vipera lebetina obtusa (VLO… 
Highly Cited
2001
Highly Cited
2001
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the… 
Highly Cited
1999
Highly Cited
1999
Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity*
Metalloprotease disintegrins are a family of membrane-anchored glycoproteins that are known to function in fertilization… 
Review
1999
Review
1999
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.
Metalloprotease-disintegrins (ADAMs) have captured our attention as key players in fertilization and in the processing of the… 
Review
1998
Review
1998
Viper Venom Disintegrins and Related Molecules
Abstract The term “disintegrin” was first used in 1990 to describe a group of viper venom-derived, nonenzymatic small proteins… 
Review
1990
Review
1990
Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms
Abstract Disintegrins represent a new class of low molecular weight, RGD-containing, cysteine-rich peptides isolated from the… 
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