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Disintegrins
Known as:
Disintegrins [Chemical/Ingredient]
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to…
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National Institutes of Health
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Related topics
Related topics
31 relations
Narrower (21)
DisBa-01, Bothrops alternatus
EMF10 protein, Eristocophis macmahoni
accutin
acostatin
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In Blood
Process of secretion
agonists
antagonists & inhibitors
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Broader (2)
Peptides
Platelet Aggregation Inhibitors
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Evolution of snake venom disintegrins by positive Darwinian selection.
Paula Juárez
,
I. Comas
,
F. González-Candelas
,
J. Calvete
Molecular biology and evolution
2008
Corpus ID: 6548447
PII-disintegrins, cysteine-rich polypeptides broadly distributed in the venoms of geographically diverse species of vipers and…
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Highly Cited
2006
Highly Cited
2006
Metalloproteinase Disintegrins ADAM8 and ADAM19 Are Highly Regulated in Human Primary Brain Tumors and their Expression Levels and Activities Are Associated with Invasiveness
D. Wildeboer
,
S. Naus
,
Q. Sang
,
J. Bartsch
,
A. Pagenstecher
Journal of Neuropathology and Experimental…
2006
Corpus ID: 18495303
Patients with primary brain tumors have bleak prognoses and there is an urgent desire to identify new markers for sensitive…
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Review
2005
Review
2005
Shedding light on ADAM metalloproteinases.
A. Huovila
,
A. Turner
,
M. Pelto-huikko
,
I. Kärkkäinen
,
R. M. Ortiz
TIBS -Trends in Biochemical Sciences. Regular ed
2005
Corpus ID: 21973872
Review
2005
Review
2005
Snake venom disintegrins: evolution of structure and function.
J. Calvete
,
C. Marcinkiewicz
,
+4 authors
L. Sanz
Toxicon
2005
Corpus ID: 35537808
Highly Cited
2003
Highly Cited
2003
Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering.
J. Calvete
,
M. Moreno‐Murciano
,
R. Theakston
,
D. Kisiel
,
C. Marcinkiewicz
Biochemical Journal
2003
Corpus ID: 8667971
We report the isolation and amino acid sequences of six novel dimeric disintegrins from the venoms of Vipera lebetina obtusa (VLO…
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Highly Cited
2001
Highly Cited
2001
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
B. Vincent
,
E. Paitel
,
+6 authors
F. Checler
Journal of Biological Chemistry
2001
Corpus ID: 30363859
We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the…
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Highly Cited
1999
Highly Cited
1999
Metalloprotease-Disintegrin MDC9: Intracellular Maturation and Catalytic Activity*
M. Roghani
,
J. Becherer
,
+7 authors
C. Blobel
Journal of Biological Chemistry
1999
Corpus ID: 45542419
Metalloprotease disintegrins are a family of membrane-anchored glycoproteins that are known to function in fertilization…
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Review
1999
Review
1999
Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.
J. Schlöndorff
,
C. Blobel
Journal of Cell Science
1999
Corpus ID: 26322369
Metalloprotease-disintegrins (ADAMs) have captured our attention as key players in fertilization and in the processing of the…
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Review
1998
Review
1998
Viper Venom Disintegrins and Related Molecules
M. McLane
,
C. Marcinkiewicz
,
S. Vijay-Kumar
,
I. Wierzbicka-Patynowski
,
S. Niewiarowski
Proceedings of the Society for Experimental…
1998
Corpus ID: 20942873
Abstract The term “disintegrin” was first used in 1990 to describe a group of viper venom-derived, nonenzymatic small proteins…
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Review
1990
Review
1990
Disintegrins: A Family of Integrin Inhibitory Proteins from Viper Venoms
R. Gould
,
M. Polokoff
,
+4 authors
S. Niewiarowski
Proceedings of the Society for Experimental…
1990
Corpus ID: 39842258
Abstract Disintegrins represent a new class of low molecular weight, RGD-containing, cysteine-rich peptides isolated from the…
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