FAQ

Disintegrins

Known as: Disintegrins [Chemical/Ingredient] 
A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. The RGD tripeptide binds to… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2018
0102019902018

Related topics

Related topics

27 relations
In BloodProcess of secretionagonistsantagonists & inhibitors
(More)

Broader (2)

PeptidesPlatelet Aggregation Inhibitors

Narrower (17)

accutinacostatinadinbitor protein, Agkistrodon halys brevicaudus stejnegeralternagin-C
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Disintegrins
physiological aspects
In Blood
Peptides
chemical synthesis
Platelet Aggregation Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Evolution of snake venom disintegrins by positive Darwinian selection.
PII-disintegrins, cysteine-rich polypeptides broadly distributed in the venoms of geographically diverse species of vipers and… (More)
  • figure 1
  • table 1
  • table 1
  • figure 2
  • table 2
Is this relevant?
2003
2003
Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering.
We report the isolation and amino acid sequences of six novel dimeric disintegrins from the venoms of Vipera lebetina obtusa (VLO… (More)
  • table 1
  • figure 1
  • table 2
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein.
We showed previously that PrPc undergoes constitutive and phorbol ester-regulated cleavage inside the 106-126 toxic domain of the… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3.
Insulin-like growth factor-binding protein (IGFBP)-3 binds the insulin-like growth factors with high affinity and modulates their… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity.
Metalloprotease disintegrins are a family of membrane-anchored glycoproteins that are known to function in fertilization… (More)
Is this relevant?
Highly Cited
1999
Highly Cited
1999
Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.
Metalloprotease disintegrins (a disintegrin and metalloprotease (ADAM) and metalloprotease, disintegrin, cysteine-rich proteins… (More)
Is this relevant?
Highly Cited
1998
Highly Cited
1998
Specific interaction of the recombinant disintegrin-like domain of MDC-15 (metargidin, ADAM-15) with integrin alphavbeta3.
MDC-15 (ADAM-15, metargidin), a membrane-anchored metalloprotease/disintegrin/cysteine-rich protein, is expressed on the surface… (More)
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Molecular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene.
A cellular disintegrin and metalloproteinase (ADAM) is a new family of genes with structural homology to the snake venom… (More)
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence.
Cellular disintegrins are a family of membrane-anchored proteins with structural homology to snake venom metalloproteases and… (More)
Is this relevant?
1993
1993
Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms.
A new series of homologous disintegrins was isolated from the venoms of new world pit viper genus Bothrops, Crotalus, and… (More)
Is this relevant?