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Snake venoms and the hemostatic system.
  • F. Markland
  • Biology, Medicine
  • Toxicon : official journal of the International…
  • 1 December 1998
Snake venoms are complex mixtures containing many different biologically active proteins and peptides. A number of these proteins interact with components of the human hemostatic system. This reviewExpand
Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia.
PURPOSE Vascular endothelial growth factor (VEGF) plays an important role in the biology of ovarian cancer (OC). Inhibitors of VEGF suppress tumor growth in OC models. Metronomic chemotherapy,Expand
Snake venom metalloproteinases.
  • F. Markland, S. Swenson
  • Chemistry, Medicine
  • Toxicon : official journal of the International…
  • 1 February 2013
Recent proteomic analyses of snake venoms show that metalloproteinases represent major components in most of the Crotalid and Viperid venoms. In this chapter we discuss the multiple activities of theExpand
Snake venom fibrin(ogen)olytic enzymes.
Snake venoms contain a number of serine and metalloproteinases and included among these are the fibrin(ogen)olytic proteinases. Some years ago it was postulated that the fibrin(ogen)olytic enzymesExpand
16 Subtilisins: Primary Structure, Chemical and Physical Properties
Publisher Summary This chapter reviews the subtilisins: the diisopropylfluorophosphate (DFP)-sensitive, extracellular, alkaline proteinaees from Bacillus subtilis and other species of Bacillus.Expand
Subtilisin Carlsberg. V. The complete sequence; comparison with subtilisin BPN'; evolutionary relationships.
Evidence is presented for the complete amino acid sequence of subtilisin Carlsberg. The protein consists of a single peptide chain of 274 residues. Comparison with subtilisin BPN' shows 84 amino acidExpand
Contortrostatin, a snake venom disintegrin, inhibits beta 1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis.
Disintegrins are Arg-Gly-Asp-containing proteins that inhibit integrin-mediated cell-cell and cell-matrix interactions. We have purified a disintegrin, contortrostatin, from Agkistrodon contortrixExpand
Purification and characterization of platelet aggregation inhibitors from snake venoms.
Proteins that inhibit glycoprotein (GP) IIb/IIIa mediated platelet aggregation have been purified from the venom of two snake species. A small platelet aggregation inhibitor (p1.AI), multisquamatinExpand
Anti-angiogenesis and RGD-containing snake venom disintegrins.
Angiogenesis is the fundamental process by which new blood vessels are formed. Extensive research has shown that this event can be co-opted by tumors to ensure their growth, survival and metastasis.Expand
Intravenous liposomal delivery of the snake venom disintegrin contortrostatin limits breast cancer progression.
Despite significant research in this area, metastatic breast cancer remains a disease with a poor prognosis. Until an effective therapy is developed, it is imperative that new treatment modalities beExpand