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Diphosphonates

Known as: bisphosphonate, biphosphonates, Diphosphonate 
Organic compounds which contain P-C-P bonds, where P stands for phosphonates or phosphonic acids. These compounds affect calcium metabolism. They… 
National Institutes of Health

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Narrower (38)

1-aminoethylene diphosphonic acid1-hydroxypentane-1,1-bisphosphonate2-iminopyrrolidone-5,5-diphosphonic acid99mTc-incadronate
5 ML zoledronic acid 0.8 MG/ML InjectionBisphosphonate [EPC]EtidronateEtidronate Disodium

Papers overview

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Highly Cited
2006
Highly Cited
2006
Solid-state NMR, crystallographic, and computational investigation of bisphosphonates and farnesyl diphosphate synthase-bisphosphonate complexes.
Bisphosphonates are a class of molecules in widespread use in treating bone resorption diseases and are also of interest as… 
2005
2005
Bisphosphonates, as a new cause of drug-induced jaw osteonecrosis: an update.
Review
2003
Review
2003
Bisphosphonates for arthritis--a confusing rationale.
2001
2001
Relationship Between Physicochemical and Osteotropic Properties of Bisphosphonic Derivatives: Rational Design for Osteotropic Drug Delivery System (ODDS)
AbstractPurpose. The objective of this investigation is to develop a rational design of Osteotropic Drug Delivery System (ODDS… 
2000
2000
Preventing bone loss after renal transplantation with bisphosphonates: we can... but should we?
Transplant-associated bone loss and fractures are significant complications associated with kidney, liver, cardiac and bone… 
1998
1998
Studies on novel bone resorption inhibitors. II. Synthesis and pharmacological activities of fused aza-heteroarylbisphosphonate derivatives.
Two new series of fused aza-heteroarylbisphosphonates (5, 8), which are structurally quite different from incadronate (YM175… 
1997
1997
Bisphosphonate therapy : Management of osteoporosis, 1997
The bisphosphonates are long-lived synthetic analogs of pyrophosphate, a natural, short-lived inhibitor of bone. Oral doses share… 
1985
1985
Effect of bisphosphonates on prostaglandin synthesis by rat bone cells and mouse calvaria in culture.
Bisphosphonates are potent inhibitors of bone resorption and also inhibit prostaglandin (PG) E2 synthesis in bone cells… 
1981
1981
A comparison of skeletal uptakes of three diphosphonates by whole-body retention: concise communication.
Twenty normal volunteers had measurements of 24-hr whole-body retention (WBR) of three structurally related Tc-99m-labeled… 
Highly Cited
1976
Highly Cited
1976
Mechanism of localization of 99mTc-labeled pyrophosphate and tetracycline in infarcted myocardium.
The gross and subcellular localizations of 99mTc-labeled pyrophosphate and tetracycline in myocardial infarcts were studied in a… 
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