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Sustained access to nutrients is a fundamental biological need, especially for proliferating cells, and controlling nutrient… Expand IDH1 and IDH2 mutations occur frequently in gliomas and acute myeloid leukemia, leading to simultaneous loss and gain of… Expand Sperm and eggs carry distinctive epigenetic modifications that are adjusted by reprogramming after fertilization. The paternal… Expand ABSTRACT Ring-cleaving dioxygenases catalyze the oxygenolytic fission of catecholic compounds, a critical step in the aerobic… Expand Indoleamine 2,3 dioxygenase (IDO) catabolizes the amino acid tryptophan. IDO-expressing immunoregulatory dendritic cells (DCs… Expand The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the DNA lesions 1… Expand HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined… Expand Aromatic hydrocarbon dioxygenases belong to a large family of Rieske non-heme iron oxygenases. The dioxygenases have a broad… Expand BACKGROUND
Pseudomonas sp. NCIB 9816-4 utilizes a multicomponent enzyme system to oxidize naphthalene to (+)-cis-(1R,2S… Expand The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the substrate by nonheme… Expand