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omega-Transaminases for the synthesis of non-racemic alpha-chiral primary amines.
Optically pure amines are highly valuable products or key intermediates for a vast number of bioactive compounds; however, efficient methods for their preparation are rare. omega-Transaminases (TAs)Expand
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Structural insights into substrate specificity and solvent tolerance in alcohol dehydrogenase ADH-'A' from Rhodococcus ruber DSM 44541.
The structure of the alcohol dehydrogenase ADH-'A' from Rhodococcus ruber reveals possible reasons for its remarkable tolerance to organic co-solvents and suggests new directions forExpand
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Asymmetric Bioreduction of Activated C=C Bonds Using Zymomonas mobilis NCR Enoate Reductase and Old Yellow Enzymes OYE 1–3 from Yeasts
The asymmetric bioreduction of C=C-bonds bearing an electron-withdrawing group, such as an aldehyde, ketone, imide, nitro, carboxylic acid, or ester moiety by a novel enoate reductase from ZymomonasExpand
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Enzymatic surface hydrolysis of poly(ethylene terephthalate) and bis(benzoyloxyethyl) terephthalate by lipase and cutinase in the presence of surface active molecules.
A lipase from Thermomyces lanuginosus and cutinases from Thermobifida fusca and Fusarium solani hydrolysed poly(ethylene terephthalate) (PET) fabrics and films and bis(benzoyloxyethyl) terephthalateExpand
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Asymmetric microbial hydrolysis of epoxides
Abstract Kinetic resolution of 2-mono- and 2,2-disubstituted epoxides was accomplished using epoxide hydrolases from bacterial and fungal origin by employing lyophilized whole microbial cells. In allExpand
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Purification and characterization of a highly selective epoxide hydrolase from Nocardia sp. EH1.
A highly enantioselective, soluble epoxide from Nocardia sp. EH1 was purified to homogeneity via a four-step procedure: (i) hydrophobic interaction chromatography on Phenyl Sepharose CL-4B, (ii)Expand
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Recent advances in the biocatalytic reduction of ketones and oxidation of sec-alcohols.
To improve the efficiency and applicability of biocatalytic redox-reactions for asymmetric ketone-reduction and enantioselective alcohol-oxidation catalyzed by nicotinamide-dependentExpand
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Asymmetric Bioreduction of CC Bonds using Enoate Reductases OPR1, OPR3 and YqjM: Enzyme‐Based Stereocontrol
Three cloned enoate reductases from the "old yellow enzyme" family of flavoproteins were investigated in the asymmetric bioreduction of activated alkenes. 12-Oxophytodienoate reductase isoenzymesExpand
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Asymmetric Synthesis of Optically Pure Pharmacologically Relevant Amines Employing ω‐Transaminases
Various w-transaminases were tested for the synthesis of enantiomerically pure amines from the corresponding ketones employing d -o rl-alanine as amino donor and lactate dehydrogenase to remove theExpand
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Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions
The purification and characterization of an organic solvent tolerant, NADH‐dependent medium‐chain secondary alcohol dehydrogenase (denoted sec‐ADH “A”) from Rhodococcus ruber DSM 44541 is reported.Expand
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