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The genome sequence of Desulfatibacillum alkenivorans AK-01: a blueprint for anaerobic alkane oxidation.
TLDR
Genomic analysis suggested a route to regenerate the fumarate needed for alkane activation via methylmalonyl-CoA and predicted the capability for syntrophic alkane metabolism, which was experimentally verified. Expand
Experimental and Theoretical Insights into the Hydrogen-Efficient Direct Hydrodeoxygenation Mechanism of Phenol over Ru/TiO2
Catalytic reduction of pyrolyzed biomass is required to remove oxygen and produce transportation fuels, but limited knowledge of how hydrodeoxygenation (HDO) catalysts work stymies the rationalExpand
Profiling mechanisms of alkane hydroxylase activity in vivo using the diagnostic substrate norcarane.
TLDR
Results from oxidations of this probe with organisms that contain the two most prevalent medium-chain-length alkane-oxidizing metalloenzymes, AlkB and cytochrome P450, indicate that these two classes of enzymes are mechanistically distinguishable and that whole-cell mechanistic assays can identify the active hydroxylase. Expand
Effects of support identity and metal dispersion in supported ruthenium hydrodeoxygenation catalysts
Abstract Substituted phenols are the most recalcitrant oxygenates in conventional pyrolysis oils and the dominant oxygenates in lower-oxygen content, formate-assisted pyrolysis oils (FAsP). RuExpand
Radical intermediates in monooxygenase reactions of rieske dioxygenases.
TLDR
The mechanism of the reaction is unknown for either the mono- or dioxygenase reactions but has been postulated to involve direct reaction of either a structurally characterized Fe(III)−hydroperoxy intermediate or the electronically equivalent Fe(V)−oxo−hydroxo intermediate formed by O−O bond cleavage before reaction with substrate. Expand
Thermodynamics of Pb(ii) and Zn(ii) binding to MT-3, a neurologically important metallothionein.
TLDR
Data indicate that Pb(2+) binding to both apo MT-3 and Zn7MT-3 is thermodynamically favourable, and implicate MT- 3 in neuronal lead biochemistry. Expand
Reaction mechanisms of non-heme diiron hydroxylases characterized in whole cells.
TLDR
Results from experiments with diethylcyclopropane, spirooctane, dimethylcyclopropan, and diethYLcyclopropanes are consistent with a restricted active site for AlkB, and evidence for the presence of a substrate-based radical during the reaction mechanism is clear. Expand
Function of Metallothionein-3 in Neuronal Cells: Do Metal Ions Alter Expression Levels of MT3?
TLDR
A study of factors proposed to affect metallothionein-3 (MT3) function was carried out to elucidate the opaque role MT3 plays in human metalloneurochemistry, pointing to the existence of a factor that differentially controls Mt3 expression. Expand
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