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Dimethindene

Known as: N,N-Dimethyl-3-(1-(2-Pyridinyl)Ethyl)-1H-Indene-2-Ethanamine, 2-(1-(2-(2-(Dimethylamino)Ethyl)Inden-3-yl)Ethyl)Pyridine, 3-(Alpha-(2'-Pyridyl)Ethyl)-2-(Beta-Dimethylaminoethyl)Indene 
A histamine H1 antagonist. It is used in hypersensitivity reactions, in rhinitis, for pruritus, and in some common cold remedies.
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Anti-Allergic AgentsAntipruriticsHistamine H1 Antagonists

Narrower (2)

Dimethindene MaleateFenistil
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Identification of a novel selective H1-antihistamine with optimized pharmacokinetic properties for clinical evaluation in the treatment of insomnia.
2006
2006
Analysis of enantiomers in biological matrices by charged cyclodextrin-mediated capillary zone electrophoresis in column-coupling arrangement with capillary isotachophoresis.
2004
2004
Identification of endothelial H1, vascular H2 and cardiac presynaptic H3 receptors in the pithed rat
SummaryIn pithed and vagotomized rats the effects of the H3 receptor agonist R-(−)-α-methylhistamine, the H1 receptor agonist 2… 
1999
1999
Semisynthetic chondroitins as chiral buffer additives in capillary electrophoresis.
1996
1996
The role of histamine H1 receptors in the thermoregulatory effect of morphine in mice.
Review
1992
Review
1992
Stereochemical studies of chiral H-1 antagonists of histamine: the resolution, chiral analysis, and biological evaluation of four antipodal pairs.
The resolution of the H-1 antihistamines chloropheniramine, dimethindene, carbinoxamine, and mebrophenhydramine is described. The… 
Review
1985
Review
1985
H1 and H2 blockade: a prophylactic principle in anaesthesia and surgery against histamine-release responses of any degree of severity: Part II.
: In the perioperative period, histamine release was shown in numerous situations and pathological states. They include diseases… 
1977
1977
[Anaphylactoid reactions following administration of plasma substitutes in man. Prevention of this side-effect of haemaccel by premedication with H1- and H2-receptor antagonists (author's transl)].
In a randomized controlled single blind trial in 50 volunteers the problem was investigated whether a combination of… 
1974
1974
Evaluation of histamine elimination curves in plasma and whole blood of several circulatory regions: A method for studying kinetics of histamine release in the whole animal
Histamine concentrations in canine whole blood and plasma were determined under several pharmacological, pathophysiological, and… 
1972
1972
Antihistamine‐monoamine oxidase inhibitor interaction in rabbits
  • J. Sinclair
  • The Journal of pharmacy and pharmacology
  • 1972
  • Corpus ID: 24199609
The ability of a drug to produce a fatal hyperpyrexia in rabbits pretreated with a monoamine oxidase inhibitor (MAOI) may be… 
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