• Publications
  • Influence
SYNTHETIC ANALGESICS: STEREOCHEMICAL CONSIDERATIONS
  • A. Beckett, A. Casy
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1 September 1954
TLDR
Active analgesics are shown to have structures which enable them to present similar surfaces to allow of their association with a proposed “analgesic receptor surface,” the essential features of which are described. Expand
Opioid Analgesics: Chemistry and Receptors
1. Introduction.- 2. 4,5-Epoxymorphinans.- 3. Morphinans.- 4. Benzomorphans.- 5. Arylmorphans and Related Compounds.- 6. Pethidine and Related 4-Phenylpiperidine Analgesics.- 7. Further AnalgesicsExpand
The biotransformation of methadone in man: Synthesis and identification of a major metabolite
After administration of methadone to man, only two basic urinary excretion products were detected, these were unchanged drug and 2‐ethyl‐1, 5‐dimethyl‐3, 3‐diphenyl‐1‐pyrroline. The hydriodide of theExpand
Sedation and histamine H1‐receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene
TLDR
The findings strongly suggest that sedation can arise from H1‐receptor antagonism alone, and provide further support for the belief that the histaminergic system is concerned with the regulation of alertness in man. Expand
Stereochemical studies of tetracycline antibiotics and their common impurities by 400 MHz 1H NMR spectroscopy
The 400 MHz 1H NMR spectra of hydrochlorides of tetracycline, chlortetracycline, doxycycline and two epimeric derivatives are reported and interpreted in terms of solute conformation in DMSO‐d6 andExpand
Opioid Analgesics
Chiral discrimination by NMR spectroscopy
Abstract The techniques for chiral recognition in NMR are reviewed with reference to applications primarily in the life sciences. A number of strategies for chiral discrimination are discussed inExpand
Molecular mechanism of delta-selectivity of indole analogs of nonpeptide opioids.
TLDR
The diminished mu-affinity of the indole analogs is a result of the loss of the carbonyl oxygen as the proton-accepting center, which the authors have previously determined to be important for recognition of the mu-receptor. Expand
Structural influences upon antihistamine activity; 3‐amino‐1‐aryl‐1‐(2‐pyridyl)propenes and related compounds
  • R. R. Ison, A. Casy
  • Chemistry, Medicine
  • The Journal of pharmacy and pharmacology
  • 1 November 1971
TLDR
The ability of the aminopropenes to antagonize histamine‐induced contractions of the guinea‐pig ileum is reported and various structure‐activity relations are discussed including stereochemistry and nature of the basic function. Expand
...
1
2
3
4
5
...