Diltiazem

Known as: 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-, Diltiazemum, (+)-cis-5-[2-(dimethylamino)Ethyl]-2,3-dihydro-3-hydroxy-2-(P-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester 
A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood… (More)

Topic mentions per year

Topic mentions per year

1975-2017
020040019752017

Papers overview

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Highly Cited
2004
Highly Cited
2004
CONTEXT Many patients with chronic angina experience anginal episodes despite revascularization and antianginal medications. In a… (More)
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Highly Cited
2002
Highly Cited
2002
Dominant mutations in sarcomere protein genes cause hypertrophic cardiomyopathy, an inherited human disorder with increased… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Whether antihypertensive drugs offer cardiovascular protection beyond blood pressure lowering has not been established… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Calcium antagonists are a first-line treatment for hypertension. The effectiveness of diltiazem, a non-dihydropyridine… (More)
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Highly Cited
2000
Highly Cited
2000
An in vitro model is proposed to account for the clinically observed inhibition of cytochrome P450 (CYP) 3A that results from… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Atrial fibrillation is the most commonly encountered sustained cardiac arrhythmia. Restoration and maintenance of… (More)
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Highly Cited
1993
Highly Cited
1993
BACKGROUND Characteristics such as age and race are often cited as determinants of the response of blood pressure to specific… (More)
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Highly Cited
1992
Highly Cited
1992
BACKGROUND Primary pulmonary hypertension is a progressive, fatal disease of unknown cause. Vasodilator drugs have been used as a… (More)
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Highly Cited
1991
Highly Cited
1991
The Multicenter Diltiazem Postinfarction Trial (MDPIT) reported no consistent diltiazem effect on new or worsened congestive… (More)
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Highly Cited
1983
Highly Cited
1983
Organic inhibitors of calcium influx prevent outward as well as inward current through cardiac calcium channels but do not slow… (More)
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