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Diltiazem

Known as: 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-, Diltiazemum, (+)-cis-5-[2-(dimethylamino)Ethyl]-2,3-dihydro-3-hydroxy-2-(P-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester 
A benzothiazepine derivative with anti-hypertensive, antiarrhythmic properties. Diltiazem blocks voltage-sensitive calcium channels in the blood… 
National Institutes of Health

Related topics

Related topics

42 relations
24 HR Diltiazem Hydrochloride 120 MG Extended Release Oral Capsule [Cartia]24 HR Diltiazem Hydrochloride 120 MG Extended Release Oral Capsule [Dilt]24 HR Diltiazem Hydrochloride 120 MG Extended Release Oral Capsule [Diltia]24 HR Diltiazem Hydrochloride 240 MG Extended Release Oral Capsule

Broader (6)

Antihypertensive AgentsAzepinesBenzazepinesCalcium Channel Blockers

Narrower (15)

CardilCardizemDilacorDilacor XR

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Biol. Pharm. Bull. 28(5) 882—885 (2005)
blockers, is widely used in the treatment of cardiovascular diseases. Clinical use of this drug has been approved for the… 
1990
1990
Oxygen Transport to Tissue XII
The theme of the July 1989 meeting emphasized respiration, but essentially all aspects of physiological oxygen transport are… 
Highly Cited
1986
Highly Cited
1986
Suppression of Atherosclerosis in Cholesterol‐Fed Rabbits by Diltiazem Injection
The effects of diltiazem, a calcium antagonist, on the development of atherosclerosis were studied in Japanese white rabbits. The… 
Highly Cited
1985
Highly Cited
1985
Superiority of combined diltiazem and propranolol therapy for angina pectoris.
Twenty-four patients with stable angina were evaluated in a 14 week crossover trial. A single-blind placebo period (baseline 1… 
Highly Cited
1983
Highly Cited
1983
Chronotropic, Inotropic, and Vasodilator Actions of Diltiazem, Nifedipine, and Verapamil: A Comparative Study of Physiological Responses and Membrane Receptor Activity
The three major, chemically distinct calcium channel-blocking drugs, diltiazem, nifedipine, and verapamil, produce coronary… 
Highly Cited
1983
Highly Cited
1983
Inhibitory effects of diltiazem on platelet activation caused by ionophore A23187 plus ADP or epinephrine in subthreshold concentrations.
We examined the effects of the slow channel Ca++ blocker diltiazem on human platelet aggregation and TXA2 generation. Diltiazem… 
Highly Cited
1981
Highly Cited
1981
Cardiovascular Effects of a New Coronary Vasodilator N‐(2‐Hydroxyethyl)nicotinamide Nitrate (SG‐75): Comparison with Nitroglycerin and Diltiazem
Summary: The cardiovascular effects of a newly developed nicotinamide derivative. N-(2-hydroxyethy1)nicotinamide nitrate (SG-75… 
Highly Cited
1980
Highly Cited
1980
Changes in cardiac mechanics and coronary blood flow of regionally ischemic porcine myocardium induced by diltiazem.
The effect of diltiazem on the relationship between myocardial blood flow and regional myocardial mechanical performance was… 
1980
1980
Myocardial blood flow following experimental coronary occlusion. Effects of diltiazem.
To determine the effects of diltiazem, a new calcium antagonist, on myocardial ischemia, two experiments were performed. The… 
1977
1977
Pharmacokinetics and bioavailability of diltiazem (CRD-401) in dog.
Pharmacokinetic behaviour of a new coronary vasodilator, the d-cis-isomer of 3-acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2… 
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