Dihydrothymine

Repair of chemically modified bases in DNA is accomplished through base excision repair (BER). This pathway is initiated by a… (More)

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it… (More)

Saccharomyces cerevisiae possesses two functional homologues (Ntg1p and Ntg2p) of the Escherichia coli endonuclease III protein… (More)

Energy deposition by ionizing radiation can lead to the formation of clustered DNA damage, i.e. more than one lesion situated… (More)

We have used thymine glycol and dihydrothymine as representative ring saturation products resulting from free-radical interaction… (More)

The structures of all diastereoisomers of 5,6-dihydroxy-5,6-dihydrothymine (thymine glycol) an 5,6-dihydrothymine, two important… (More)

The processing of unrepaired DNA lesions is a key to understanding and predicting the biological end points of particular DNA… (More)

Antibodies to dihydrothymine were elicited by immunizing rabbits with dihydrothymidine monophosphate conjugated by carbodiimide… (More)

In the urine of a child with unexplained convulsions large amounts of uracil and thymine were detected by gas chromatography… (More)

Rat liver dihydrothymine dehydrogenase, the rate-limiting enzyme of thymidine and uridine degradation, was purified to… (More)