Dihydrothymine

Repair of chemically modified bases in DNA is accomplished through base excision repair (BER). This pathway is initiated by a… Expand

Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it… Expand

Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damage, which are thought to reflect the biological… Expand

Energy deposition by ionizing radiation can lead to the formation of clustered DNA damage, i.e. more than one lesion situated… Expand

Endonuclease VIII, a novel presumptive DNA repair enzyme, was isolated from Escherichia coli by FPLC1 purification. The enzyme… Expand

We have used thymine glycol and dihydrothymine as representative ring saturation products resulting from free-radical interaction… Expand

The processing of unrepaired DNA lesions is a key to understanding and predicting the biological end points of particular DNA… Expand

In the urine of a child with unexplained convulsions large amounts of uracil and thymine were detected by gas chromatography… Expand

Rat liver dihydrothymine dehydrogenase, the rate-limiting enzyme of thymidine and uridine degradation, was purified to… Expand

TRITIATED thymidine is well recognised to be a highly specific precursor for DNA syntbesis in mammalian cells. During the past… Expand