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Repair of chemically modified bases in DNA is accomplished through base excision repair (BER). This pathway is initiated by a… Expand Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it… Expand Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damage, which are thought to reflect the biological… Expand Energy deposition by ionizing radiation can lead to the formation of clustered DNA damage, i.e. more than one lesion situated… Expand We have used thymine glycol and dihydrothymine as representative ring saturation products resulting from free-radical interaction… Expand The processing of unrepaired DNA lesions is a key to understanding and predicting the biological end points of particular DNA… Expand The UvrABC nuclease complex recognizes a wide spectrum of DNA lesions including pyrimidine dimers, bulky chemical adducts and O6… Expand In the urine of a child with unexplained convulsions large amounts of uracil and thymine were detected by gas chromatography… Expand Rat liver dihydrothymine dehydrogenase, the rate-limiting enzyme of thymidine and uridine degradation, was purified to… Expand TRITIATED thymidine is well recognised to be a highly specific precursor for DNA syntbesis in mammalian cells. During the past… Expand