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Dihydrothymine

National Institutes of Health

Related topics

Related topics

3 relations
Dihydrothymine/Creatinine:SRto:Pt:Urine:QnDihydrothymine:SCnc:Pt:CSF:Qn

Broader (1)

Thymine

Papers overview

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Highly Cited
2005
Highly Cited
2005
XRCC1 interactions with multiple DNA glycosylases: a model for its recruitment to base excision repair.
Repair of chemically modified bases in DNA is accomplished through base excision repair (BER). This pathway is initiated by a… Expand
Highly Cited
2001
Highly Cited
2001
Lethal outcome of a patient with a complete dihydropyrimidine dehydrogenase (DPD) deficiency after administration of 5-fluorouracil: frequency of the common IVS14+1G>A mutation causing DPD deficiency…
Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme in the catabolism of 5-fluorouracil (5FU), and it… Expand
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Highly Cited
2000
Highly Cited
2000
Clustered DNA Damage, Influence on Damage Excision by XRS5 Nuclear Extracts and Escherichia coli Nth and Fpg Proteins*
Ionizing radiation and radiomimetic anticancer agents induce clustered DNA damage, which are thought to reflect the biological… Expand
Highly Cited
1995
Highly Cited
1995
The action of Escherichia coli endonuclease III on multiply damaged sites in DNA.
Energy deposition by ionizing radiation can lead to the formation of clustered DNA damage, i.e. more than one lesion situated… Expand
Highly Cited
1993
Highly Cited
1993
Thymine ring saturation and fragmentation products: lesion bypass, misinsertion and implications for mutagenesis.
We have used thymine glycol and dihydrothymine as representative ring saturation products resulting from free-radical interaction… Expand
Highly Cited
1991
Highly Cited
1991
Processing of DNA base damage by DNA polymerases. Dihydrothymine and beta-ureidoisobutyric acid as models for instructive and noninstructive lesions.
The processing of unrepaired DNA lesions is a key to understanding and predicting the biological end points of particular DNA… Expand
Highly Cited
1990
Highly Cited
1990
UvrABC nuclease complex repairs thymine glycol, an oxidative DNA base damage.
The UvrABC nuclease complex recognizes a wide spectrum of DNA lesions including pyrimidine dimers, bulky chemical adducts and O6… Expand
Highly Cited
1984
Highly Cited
1984
Elevated urine, blood and cerebrospinal fluid levels of uracil and thymine in a child with dihydrothymine dehydrogenase deficiency.
In the urine of a child with unexplained convulsions large amounts of uracil and thymine were detected by gas chromatography… Expand
Highly Cited
1981
Highly Cited
1981
Purification and properties of dihydrothymine dehydrogenase from rat liver.
Rat liver dihydrothymine dehydrogenase, the rate-limiting enzyme of thymidine and uridine degradation, was purified to… Expand
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1964
1964
The Incorporation and Degradation of Pyrimidine DNA Precursors by Human Leucocytes
TRITIATED thymidine is well recognised to be a highly specific precursor for DNA syntbesis in mammalian cells. During the past… Expand
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