Dihydroergotamine

Known as: (2R,4R,7R)-N-[(1S,2S,4R,7S)-7-benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraene-4-carboxamide, 9,10-dihydroergotamine, Dihydroergotamin 
A 9,10alpha-dihydro derivative of ERGOTAMINE. It is used as a vasoconstrictor, specifically for the therapy of MIGRAINE DISORDERS.
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
BACKGROUND Migraine is one of the most frequent disabling neurological conditions with a major impact on the patients' quality of… (More)
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Review
2003
Review
2003
Ergotamine and dihydroergotamine share structural similarities with the adrenergic, dopaminergic, and serotonergic… (More)
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Highly Cited
1998
Highly Cited
1998
OBJECTIVE To assess the new "Lund therapy" of posttraumatic brain edema, based on principles for brain-volume regulation and… (More)
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Review
1997
Review
1997
The ergot alkaloids are a family of chemical entities that have many pharmacologic effects. Their diversity results from their… (More)
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Highly Cited
1993
Highly Cited
1993
Both clinical and physiological consideration of migraine suggests that the pathophysiology of the syndrome is intimately linked… (More)
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Highly Cited
1991
Highly Cited
1991
Vasoactive neuropeptides, present in unmyelinated C-fibers, can be released from perivascular sensory axons by antidromic… (More)
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Review
1988
Review
1988
The results of randomized clinical trials evaluating commonly used methods of deep vein thrombosis (DVT) prophylaxis in moderate… (More)
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Highly Cited
1986
Highly Cited
1986
For patients with chronic intractable headache, we compared a new treatment and a traditional one. Fifty-five patients (36… (More)
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1982
1982
1 The pharmacokinetics of dihydroergotamine (DHE) in plasma were examined in six normotensive subjects after single acute doses… (More)
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Highly Cited
1957
Highly Cited
1957
There are two kinds of tryptamine receptor in the guinea-pig ileum, namely the M receptors which can be blocked with morphine and… (More)
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