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Dideaza-5,6,7,8-Tetrahydrofolic Acid

Known as: DDATHF 
An antimetabolite and folate analogue with anti-proliferative activity. Dideazatetrahydrofolic acid inhibits activity of glycinamide ribonucleotide… 
National Institutes of Health

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Lometrexol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid
SummaryLometrexol is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for… 
Review
2004
Review
2004
Biological and biochemical properties of new anticancer folate antagonists
SummaryWe review the biology and biochemical pharmacology of four antifolates that were recently introduced into clinical trial… 
Highly Cited
2002
Highly Cited
2002
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
2000
2000
Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
A murine leukemia cell line was identified that is highly resistant to methotrexate (MTX), due to impaired transport, but fully… 
1995
1995
5,10-Dideazatetrahydrofolic acid reduces toxicity and deoxyadenosine triphosphate pool, expansion in cultured L1210 cells treated with inhibitors of thymidylate synthase.
Highly Cited
1994
Highly Cited
1994
Impact of dietary folic acid on reduced folates in mouse plasma and tissues. Relationship to dideazatetrahydrofolate sensitivity.
1994
1994
Mechanism of cytotoxicity of 5,10-dideazatetrahydrofolic acid in human ovarian carcinoma cells in vitro and modulation of the drug activity by folic or folinic acid.
Inhibition of clonogenic potential by the glycinamideribonucleosyl transformylase inhibitor 5,10-dideazatetrahydrofolic acid… 
1993
1993
Cytotoxicity of antifolate inhibitors of thymidylate and purine synthesis to WiDr colonic carcinoma cells.
We have studied the cytotoxicity of 5,10-dideazatetrahydrofolate (DDATHF) and of D-1694 to human WiDr colonic carcinoma cells as… 
Highly Cited
1991
Highly Cited
1991
Structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase.
We have investigated the structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDATHF) that determine the activity of… 
1988
1988
Synthesis and biological properties of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid.
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