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Dideaza-5,6,7,8-Tetrahydrofolic Acid

Known as: DDATHF 
An antimetabolite and folate analogue with anti-proliferative activity. Dideazatetrahydrofolic acid inhibits activity of glycinamide ribonucleotide… 
National Institutes of Health

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Lometrexol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
A Phase I clinical study of the antipurine antifolate lometrexol (DDATHF) given with oral folic acid
SummaryLometrexol is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for… 
Review
2004
Review
2004
Biological and biochemical properties of new anticancer folate antagonists
SummaryWe review the biology and biochemical pharmacology of four antifolates that were recently introduced into clinical trial… 
2004
2004
Induction of HL-60 leukemia cell differentiation by tetrahydrofolate inhibitors of de novo purine nucleotide biosynthesis
Summary5,10-Dideazatetrahydrofolic acid (DDATHF) is a folate antimetabolite that shows activity against glycinamide… 
Highly Cited
2002
Highly Cited
2002
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
2000
2000
Sensitivity to 5,10-dideazatetrahydrofolate is fully conserved in a murine leukemia cell line highly resistant to methotrexate due to impaired transport mediated by the reduced folate carrier.
A murine leukemia cell line was identified that is highly resistant to methotrexate (MTX), due to impaired transport, but fully… 
1996
1996
Phase I study of the antipurine antifolate lometrexol (DDATHF) with folinic acid rescue.
Lometrexol (5,10-dideazatetrahydrofolic acid) is a new antifolate that is highly selective in inhibiting the key enzyme of purine… 
1995
1995
Antitumor activity of antifolate inhibitors of thymidylate and purine synthesis in human soft tissue sarcoma cell lines with intrinsic resistance to methotrexate.
We examined the antitumor effects of two antifolate inhibitors of thymidylate synthesis, N-(5-[N-(3, 4-dihydro-2-methyl-4… 
1994
1994
Whole-body autoradiographic disposition and plasma pharmacokinetics of 5,10-dideazatetrahydrofolic acid in mice fed folic acid-deficient or regular diets.
The effect of folic acid depletion on the tissue distribution and plasma pharmacokinetics of the oncolytic agent 5,10… 
1993
1993
Determinants of the disparate antitumor activities of (6R)-5,10-dideaza-5,6,7,8-tetrahydrofolate and methotrexate toward human lymphoblastic leukemia cells, characterized by severely impaired…
1988
1988
Synthesis and biological properties of 5,10-dideaza-5,6,7,8-tetrahydrofolic acid.
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