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Lometrexol

Known as: L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, LMTX, 6R-5,10-Dideazatetrahydrofolate 
A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide… Expand
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases… Expand
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Highly Cited
2015
Highly Cited
2015
Methylthioninium (MT) is a tau aggregation inhibitor with therapeutic potential in Alzheimer’s disease (AD). MT exists in… Expand
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Review
2014
Review
2014
Many trials of drugs aimed at preventing or clearing β-amyloid pathology have failed to demonstrate efficacy in recent years and… Expand
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Highly Cited
2003
Highly Cited
2003
We have studied the molecular basis of drug resistance in human CCRF-CEM leukemia cells exposed to high dose intermittent pulses… Expand
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Highly Cited
2003
Highly Cited
2003
istry Core Facility for the use of the fluorescence plate reader. The work in the authors’ labs was supported by NIH grants… Expand
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2002
2002
We determined the mechanisms of resistance of human CCRF-CEM leukemia cells to methotrexate (MTX) vs. those to six novel… Expand
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Highly Cited
2001
Highly Cited
2001
The presence of sequence variants in the human reduced folate carrier (hRFC) was assessed in leukemia blasts from children with… Expand
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Highly Cited
1998
Highly Cited
1998
CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective… Expand
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Highly Cited
1995
Highly Cited
1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… Expand
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1993
1993
Methylthioadenosine (MeSAdo) phosphorylase, a purine metabolic enzyme, is present in all normal mammalian tissues. A deficiency… Expand
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