Lometrexol

Known as: L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, LMTX, 6R-5,10-Dideazatetrahydrofolate 
A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2016
05101519872016

Papers overview

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2003
2003
We have studied the molecular basis of drug resistance in human CCRF-CEM leukemia cells exposed to high dose intermittent pulses… (More)
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2001
2001
The presence of sequence variants in the human reduced folate carrier (hRFC) was assessed in leukemia blasts from children with… (More)
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Highly Cited
1998
Highly Cited
1998
CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective… (More)
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1996
1996
Recent clinical trials with lometrexol [(6R)-5,10-dideazatetrahydrofolate] have revealed a level of toxicity in humans that was… (More)
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1996
1996
Lometrexol is an antifolate which inhibits glycinamide ribonucleotide formyltransferase (GARFT), an enzyme essential for de novo… (More)
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1996
1996
Methylthioadenosine phosphorylase (MTAP), an enzyme involved in purine and methionine metabolism, is present in all normal… (More)
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Highly Cited
1995
Highly Cited
1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… (More)
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1993
1993
A subline of H35 hepatoma cells has been developed which exhibits 80-fold resistance to 5,10-dideazatetrahydrofolate, an… (More)
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1992
1992
Two membrane folate receptor (MFR) isoforms are present in human tissues i.e. MFR-1 (e.g. placenta) and MFR-2 (e.g. placenta, KB… (More)
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Highly Cited
1989
Highly Cited
1989
5,10-Dideazatetrahydrofolate (DDATHF) is a new antimetabolite designed as an inhibitor of folate metabolism at sites other than… (More)
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