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Lometrexol

Known as: L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, LMTX, 6R-5,10-Dideazatetrahydrofolate 
A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide… 
National Institutes of Health

Papers overview

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Review
2016
Review
2016
Abnormal deposition of misprocessed and aggregated proteins is a common final pathway of most neurodegenerative diseases… 
Highly Cited
2015
Highly Cited
2015
Methylthioninium (MT) is a tau aggregation inhibitor with therapeutic potential in Alzheimer’s disease (AD). MT exists in… 
Review
2014
Review
2014
Highly Cited
2003
Highly Cited
2003
We have studied the molecular basis of drug resistance in human CCRF‐CEM leukemia cells exposed to high dose intermittent pulses… 
Highly Cited
1998
Highly Cited
1998
CEM/MTX is a subline of human CCRF-CEM leukemia cells which displays >200-fold resistance to methotrexate (MTX) due to defective… 
Highly Cited
1995
Highly Cited
1995
The transport properties and growth-inhibitory potential of 37 classic and novel antifolate compounds have been tested in vitro… 
Highly Cited
1991
Highly Cited
1991
We have investigated the structural features of 5,10-dideaza-5,6,7,8-tetrahydrofolate (DDATHF) that determine the activity of… 
Highly Cited
1989
Highly Cited
1989
5,10-Dideazatetrahydrofolate (DDATHF) is a new antimetabolite designed as an inhibitor of folate metabolism at sites other than…