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Diamide

Known as: Diamide [Chemical/Ingredient], Bisdimethylamide, Diazodicarboxylic Acid, Diazodicarboxylic Acid Bisdimethylamide 
A sulfhydryl reagent which oxidizes sulfhydryl groups to the disulfide form. It is a radiation-sensitizing agent of anoxic bacterial and mammalian… 
National Institutes of Health

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9 relations

Narrower (3)

4-epiaglain Acurcamideelliptinol

Broader (2)

Radiation-Sensitizing AgentsSulfhydryl Reagents
analogs & derivativesaspects of radiation effectschemical synthesisstandards characteristics

Papers overview

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Highly Cited
1986
Highly Cited
1986
Tissue distribution properties of technetium-99m-diamide-dimercaptide complexes and potential use as renal radiopharmaceuticals.
A series of new ligands and the corresponding technetium-99m chelates based on diamide dimercaptide donor groups were synthesized… 
1983
1983
Spindle disturbances in mammalian cells. I. Changes in the quantity of free sulfhydryl groups in relation to survival and C-mitosis in V79 Chinese hamster cells after treatment with colcemid, diamide…
Asynchronously growing V79 Chinese hamster cells were treated with colcemid, diamide, carbaryl and methyl mercury, which are all… 
1981
1981
Methotrexate analogues. 13. Chemical and pharmacological studies on amide, hydrazide, and hydroxamic acid derivatives of the glutamate side chain.
Carbodiimide-mediated condensation of 4-amino-4-deoxy-N10-methylpteroic acid (APA) with several alkyl, aralkyl, and aryl amines… 
1979
1979
Structure-activity relationships of dimeric Catharanthus alkaloids. 2. Experimental antitumor activities of N-substituted deacetylvinblastine amide (vindesine) sulfates.
While structure-activity relationships for vinblastine (VLB), vincristine, deacetyl-VLB, and deacetyl-VLB amide (vindesine, VDS… 
1979
1979
Antileukemic activity of derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate).
A series of phenyl-substituted derivatives of 1,2-dimethyl-3,4-bis(hydroxymethyl)-5-phenylpyrrole bis(N-methylcarbamate) (1) were… 
1978
1978
The reduction of diamide by rat liver mitochondria and the role of glutathione.
Diamide is reduced by mitochondria utilizing endogenous substrates with Vmax. 20nmol/min per mg of protein and Km 75micrometer… 
1977
1977
Synthesis and antileukemic activity of 5-substituted 2,3-dihydro-6,7-bis(hydroxymethyl)-1H-pyrrolizine diesters.
Treatment of N-acylproline derivatives, 2, with acetic anhydride--dimethyl acetylenedicarboxylate (DMAD) gave 5-substituted… 
1975
1975
Radiosensitization of hypoxic mammalian cells by diamide. I. Effects of experimental conditions on survival.
Diamide sensitizes hypoxic mammalian cells to x radiation in a complex manner. It sensitizes CHO cells more effectively than V79… 
1975
1975
Radiation chemical studies of the sensitizer Diamide.
A detailed study of the radiation chemistry of the radiosensitizer Diamide (diazenedicarboxylic acid bis-dimethylamide) using… 
1966
1966
Chemical modification of hemoglobins: a study of conformation restraint by internal bridging.
The equilibrium between mammalian hemoglobins and oxygen has long been recognized to be a reflection of functional interactions…