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Desmocollins

Known as: Desmocollins [Chemical/Ingredient], desmocollin 
A group of desmosomal cadherins with cytoplasmic tails that are divergent from those of classical CADHERINS. Their intracytoplasmic domains bind… Expand
National Institutes of Health

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CadherinsIn BloodProcess of secretionagonists
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DSC1 protein, human

Papers overview

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Highly Cited
2016
Highly Cited
2016
Structural basis of adhesive binding by desmocollins and desmogleins
Significance Desmosomes are crucial for the integrity of tissues that undergo mechanical stress. Their intercellular attachments… Expand
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Review
2009
Review
2009
The desmosome.
Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins… Expand
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Highly Cited
2008
Highly Cited
2008
Loss of desmocollin 3 in mice leads to epidermal blistering
Desmocollin 3 (DSC3) belongs to a subfamily of cadherins and is a major component of desmosomes in keratinocytes of stratified… Expand
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Highly Cited
2006
Highly Cited
2006
IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis.
IL-22 is an IFN-IL-10 cytokine family member, which is produced by activated Th1 and NK cells and acts primarily on epithelial… Expand
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Highly Cited
2004
Highly Cited
2004
Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7.
Corneodesmosin (CDSN), desmoglein 1 (DSG1), and desmocollin 1 (DSC1) are adhesive proteins of the extracellular part of the… Expand
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Highly Cited
2004
Highly Cited
2004
Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion.
Desmoglein 1 (Dsg1) is a component of desmosomes present in the upper epidermis and can be targeted by autoimmune antibodies or… Expand
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Highly Cited
2001
Highly Cited
2001
Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation
The desmosomal cadherin desmocollin (Dsc)1 is expressed in upper epidermis where strong adhesion is required. To investigate its… Expand
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Review
2000
Review
2000
Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members.
Cadherins play an important role in specific cell-cell adhesion events. Their expression appears to be tightly regulated during… Expand
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Highly Cited
1997
Highly Cited
1997
Human desmocollin 1 (Dsc1) is an autoantigen for the subcorneal pustular dermatosis type of IgA pemphigus.
IgA pemphigus showing IgA anti-keratinocyte cell surface autoantibodies is divided into subcorneal pustular dermatosis (SPD) and… Expand
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Highly Cited
1991
Highly Cited
1991
Endocytosis of junctional cadherins in bovine kidney epithelial (MDBK) cells cultured in low Ca2+ ion medium
The release of intercellular contacts in MDBK cells, initiated by the depletion of Ca2+ ions from the culture medium, results in… Expand
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