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Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion

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Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin

TLDR
It is reported that fresh murine LC express cadherins, and that LC adhere to KC in vitro through E-cadherin, and to begin to elucidate mechanisms involved in LC trafficking, LC-keratinocyte (KC) interactions are characterized.
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Monitoring of methyl jasmonate-responsive genes in Arabidopsis by cDNA macroarray: self-activation of jasmonic acid biosynthesis and crosstalk with other phytohormone signaling pathways.

TLDR
The results suggest the existence of a positive feedback regulatory system for JA biosynthesis and the possibility of crosstalk between JA signaling and other signaling pathways.
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Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.

TLDR
The clinical and pathological similarities among these forms of pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome are discussed.
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Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.

TLDR
It is suggested that pemphigus autoantibodies inhibit the adhesive function of desmoglein proteins, and it is demonstrated that either Dsg1 or Dsg3 alone is sufficient to maintain keratinocyte adhesion.
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Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins.

TLDR
This ELISA provides a sensitive and highly specific assay for the diagnosis of patients with PV and PF, the correlation of disease activity with serum Ab levels, and a novel tool for investigating the immunopathogenesis of pemphigus.
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Induction of Pemphigus Phenotype by a Mouse Monoclonal Antibody Against the Amino-Terminal Adhesive Interface of Desmoglein 3 1

TLDR
The pathogenic heterogeneity among anti-Dsg3 IgG Abs due to their epitopes is demonstrated, and the direct inhibition of adhesive interaction of Dsg as an initial molecular event of blister formation in pemphigus is suggested.
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Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1

TLDR
It is shown here that exfoliative toxin A cleaved mouse and human Dsg1, but not closely related cadherins such as Dsg3.
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External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers

Outermost barriers are critical for terrestrial animals to avoid desiccation and to protect their bodies from foreign insults. Mammalian skin consists of two sets of barriers: stratum corneum (SC)…
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Consensus statement on definitions of disease, end points, and therapeutic response for pemphigus.

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