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Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion
Pemphigus vulgaris (PV) is a life-threatening skin disease in which autoantibodies against a keratinocyte cell surface 130 kd glycoprotein, PV antigen (PVA), cause loss of cell-cell adhesion, withExpand
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Pemphigus, bullous impetigo, and the staphylococcal scalded-skin syndrome.
This review discusses the autoantibodies in pemphigus vulgaris and pemphigus foliaceus and the clinical and pathological similarities among these forms of pemphigus, bullous impetigo, and theExpand
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Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins.
Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are autoimmune skin diseases caused by autoantibodies against desmoglein (Dsg) 3 and Dsg1, respectively. Routine immunofluorescence testing ofExpand
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Adhesion of epidermal Langerhans cells to keratinocytes mediated by E-cadherin
LANGERHANS cells (LC) are the principal accessory cells present in epidermis1. Because LC have limited capacity for self-renewal2, epidermis is continually repopulated by as-yet uncharacterized boneExpand
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Monitoring of methyl jasmonate-responsive genes in Arabidopsis by cDNA macroarray: self-activation of jasmonic acid biosynthesis and crosstalk with other phytohormone signaling pathways.
Jasmonates mediate various physiological events in plant cells such as defense responses, flowering, and senescence through intracellular and intercellular signaling pathways, and the expression of aExpand
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Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris.
Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PVExpand
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Toxin in bullous impetigo and staphylococcal scalded-skin syndrome targets desmoglein 1
Exfoliative toxin A, produced by Staphylococcus aureus, causes blisters in bullous impetigo and its more generalized form, staphylococcal scalded-skin syndrome. The toxin shows exquisite specificityExpand
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The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile.
BACKGROUND Some patients with pemphigus vulgaris (PV) have mucous membrane erosions with minimal skin involvement (mucosal dominant type), and others show extensive skin blisters and erosions inExpand
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External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriers
Outermost barriers are critical for terrestrial animals to avoid desiccation and to protect their bodies from foreign insults. Mammalian skin consists of two sets of barriers: stratum corneum (SC)Expand
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Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis.
Staphylococcus aureus skin colonization is universal in atopic dermatitis and common in cancer patients treated with epidermal growth factor receptor inhibitors. However, the causal relationship ofExpand
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