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Dependovirus

Known as: Dependoparvovirus, adeno-associated virus, Dependoviruses 
A genus of the family PARVOVIRIDAE, subfamily PARVOVIRINAE, which are dependent on a coinfection with helper adenoviruses or herpesviruses for their… 
National Institutes of Health

Related topics

Related topics

7 relations
AAVS1 geneSatellite Virusesaspects of radiation effectsphysiological aspects

Narrower (1)

Adeno-Associated Virus

Broader (2)

ParvoviridaeParvovirus

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
A multifunctional AAV–CRISPR–Cas9 and its host response
CRISPR–Cas9 delivery by adeno-associated virus (AAV) holds promise for gene therapy but faces critical barriers on account of its… 
Highly Cited
2015
Highly Cited
2015
Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas
Hepatocellular carcinomas (HCCs) are liver tumors related to various etiologies, including alcohol intake and infection with… 
Highly Cited
2012
Highly Cited
2012
AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness
Repeat administration of gene therapy to the contralateral retina of three congenitally blind patients was safe and resulted in… 
Highly Cited
2010
Highly Cited
2010
Prevalence of serum IgG and neutralizing factors against adeno-associated virus (AAV) types 1, 2, 5, 6, 8, and 9 in the healthy population: implications for gene therapy using AAV vectors.
Adeno-associated viruses (AAVs) are small, nonenveloped single-stranded DNA viruses that require helper viruses to facilitate… 
Highly Cited
2008
Highly Cited
2008
Next generation of adeno-associated virus 2 vectors: Point mutations in tyrosines lead to high-efficiency transduction at lower doses
Recombinant adeno-associated virus 2 (AAV2) vectors are in use in several Phase I/II clinical trials, but relatively large vector… 
Highly Cited
2008
Highly Cited
2008
Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.
Late infantile neuronal ceroid lipofuscinosis (LINCL) is an autosomal recessive, neurodegenerative lysosomal storage disease… 
Highly Cited
2005
Highly Cited
2005
Packaging Capacity of Adeno-Associated Virus Serotypes: Impact of Larger Genomes on Infectivity and Postentry Steps
ABSTRACT The limited packaging capacity of adeno-associated virus (AAV) precludes the design of vectors for the treatment of… 
Highly Cited
2004
Highly Cited
2004
Recombinant AAV viral vectors pseudotyped with viral capsids from serotypes 1, 2, and 5 display differential efficiency and cell tropism after delivery to different regions of the central nervous…
Highly Cited
2004
Highly Cited
2004
Systemic delivery of genes to striated muscles using adeno-associated viral vectors
A major obstacle limiting gene therapy for diseases of the heart and skeletal muscles is an inability to deliver genes… 
Highly Cited
2002
Highly Cited
2002
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery
The feasibility of gene therapy for cardiomyopathy, heart failure and other chronic cardiac muscle diseases is so far unproven… 
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