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Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming.
A Defect in the Kv Channel-Interacting Protein 2 (KChIP2) Gene Leads to a Complete Loss of I to and Confers Susceptibility to Ventricular Tachycardia
Fibulin-5/DANCE is essential for elastogenesis in vivo
It is reported that fibulin-5 (also known as DANCE), a recently discovered integrin ligand, is an essential determinant of elastic fibre organization and may provide anchorage of elastic fibres to cells, thereby acting to stabilize and organize elastic fibre in the skin, lung and vasculature.
Lentiviral vectors: basic to translational.
In the present high-throughput '-omics' era, the commercial availability of premade lentiviral vectors, which are engineered to express or silence genome-wide genes, accelerates the rapid expansion of this vector technology.
Continuous high-titer HIV-1 vector production
- Y. Ikeda, Y. Takeuchi, F. Martín, F. Cosset, K. Mitrophanous, M. Collins
- BiologyNature Biotechnology
- 1 May 2003
It is reported that expression of HIV-1 Gag-Pol by a murine leukemia virus (MLV) vector allows constitutive, long-term, high-level (up to 850 ng/ml p24) expression of AIDS type 1 Gag.
Regression of abdominal aortic aneurysm by inhibition of c-Jun N-terminal kinase
It is shown that JNK programs a gene expression pattern in different cell types that cooperatively enhances the degradation of the extracellular matrix while suppressing biosynthetic enzymes of the Extracellular Matrix.
Postentry Restriction to Human Immunodeficiency Virus-Based Vector Transduction in Human Monocytes
The ability of HIV-1-based vectors to transduce human monocytes, monocyte-derived macrophages, and dendritic cells (DCs) was examined, in order to develop an efficient protocol for antigen gene delivery to human antigen-presenting cells.
Catecholaminergic Polymorphic Ventricular Tachycardia Is Caused by Mutation-Linked Defective Conformational Regulation of the Ryanodine Receptor
A single point mutation within the RyR2 sensitizes the channel to agonists and reduces the threshold of luminal [Ca2+] for activation, primarily mediated by defective interdomain interaction within the R2474S/+ KI mice.
Alpha Interferon Enhances TRIM5α-Mediated Antiviral Activities in Human and Rhesus Monkey Cells
It is demonstrated that interferon alpha (IFN-α) treatment upregulates TRIM5α mRNA in rhesus monkey cells, which correlates with the enhanced TRim5α-mediated pre- and postintegration blocks of human immunodeficiency virus replication.
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery
Transcoronary gene transfer of S16EPLN via rAAV vector is a potential therapy for progressive dilated cardiomyopathy and associated heart failure and protecting cardiac myocytes from cytopathic plasma-membrane disruption.