Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas

  title={Recurrent AAV2-related insertional mutagenesis in human hepatocellular carcinomas},
  author={Jean-Charles Nault and Shalini Datta and Sandrine Imbeaud and Andrea Franconi and Maxime Mallet and Gabrielle Couchy and Eric Letouz{\'e} and Camilla Pilati and Benjamin Verret and J. -F. Blanc and Charles Balabaud and Julien Calderaro and Alexis Laurent and M{\'e}lanie Letexier and Paulette Bioulac-Sage and Fabien Calvo and Jessica Zucman-Rossi},
  journal={Nature Genetics},
Hepatocellular carcinomas (HCCs) are liver tumors related to various etiologies, including alcohol intake and infection with hepatitis B (HBV) or C (HCV) virus. Additional risk factors remain to be identified, particularly in patients who develop HCC without cirrhosis. We found clonal integration of adeno-associated virus type 2 (AAV2) in 11 of 193 HCCs. These AAV2 integrations occurred in known cancer driver genes, namely CCNA2 (cyclin A2; four cases), TERT (telomerase reverse transcriptase… CONTINUE READING
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Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation

  • C Pilati
  • Cancer Cell 25,
  • 2014
1 Excerpt

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

  • Nault, J.C
  • Nat. Commun
  • 2013

Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and Cufflinks

  • C Trapnell
  • Nat. Protoc
  • 2012

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