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DROSHA gene

Known as: drosha ribonuclease III, drosha, ribonuclease type III, RIBONUCLEASE III, NUCLEAR 
This gene plays a role in the processing of microRNA in the nucleus.
National Institutes of Health

Related topics

Related topics

5 relations
HydrolysisRNA DegradationRNA ProcessingRNASEN wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
MicroRNA-128-3p-mediated depletion of Drosha promotes lung cancer cell migration
Alteration in microRNAs (miRNAs) expression is a frequent finding in human cancers. In particular, widespread miRNAs down… 
2014
2014
Murine Follicular Development Requires Oocyte DICER, but Not DROSHA1
ABSTRACT Both DICER and DROSHA are RNase III enzymes involved in the biogenesis of small noncoding RNAs. DROSHA cleaves the stem… 
2014
2014
A central role for the primary microRNA stem in guiding the position and efficiency of Drosha processing of a viral pri-miRNA
This paper addresses the mechanism of recognition and cleavage of primary microRNAs (pri-miRNAs) by the Microprocessor (DGCR8… 
2014
2014
Drosha-independent DGCR8/Pasha pathway regulates neuronal morphogenesis
Significance Understanding the neuronal functions of diverse RNA pathways will lead to treatments of human neurological diseases… 
Highly Cited
2013
Highly Cited
2013
DICER1, DROSHA and miRNAs in patients with non-small cell lung cancer: implications for outcomes and histologic classification.
The clinical and functional significance of RNA-interference machinery in lung cancer is poorly understood. Besides, microRNAs… 
Highly Cited
2012
Highly Cited
2012
Deep annotation of mouse iso-miR and iso-moR variation
With a dataset of more than 600 million small RNAs deeply sequenced from mouse hippocampal and staged sets of mouse cells that… 
2011
2011
Drosha regulates hMSCs cell cycle progression through a miRNA independent mechanism.
2011
2011
A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs.
Canonical animal microRNAs (miRNAs) are ∼22-nt regulatory RNAs generated by stepwise cleavage of primary hairpin transcripts by… 
Highly Cited
2008
Highly Cited
2008
A Drosophila pasha Mutant Distinguishes the Canonical MicroRNA and Mirtron Pathways
ABSTRACT Canonical primary microRNA (miRNA) transcripts and mirtrons are proposed to transit distinct nuclear pathways en route… 
Highly Cited
2006
Highly Cited
2006
A Novel Assay for Viral MicroRNA Function Identifies a Single Nucleotide Polymorphism That Affects Drosha Processing
ABSTRACT MicroRNAs (miRNAs) are a class of ∼22-nucleotide noncoding RNAs that inhibit the expression of specific target genes at… 
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