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DOT1L gene

Known as: KMT4, DOT1L, DOT1 
This gene is involved in epigenetic control of gene expression.
National Institutes of Health

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DOT1L wt Allele
Gene ExpressionHistone-Lysine N-Methyltransferase H3 Lysine-79 Specific, HumanMethylationProtein methylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Recent progress in developing selective inhibitors of protein methyltransferases.
2017
2017
Discovery of Novel Disruptor of Silencing Telomeric 1-Like (DOT1L) Inhibitors using a Target-Specific Scoring Function for the (S)-Adenosyl-l-methionine (SAM)-Dependent Methyltransferase Family.
The disruptor of telomeric silencing 1-like (DOT1L) protein is a histone H3K79 methyltransferase that plays a key role in… 
Review
2016
Review
2016
Long Non-coding RNAs in Urologic Malignancies: Functional Roles and Clinical Translation
Early diagnosis and surveillance for metastasis and recurrences are critical issues of urologic cancer. Deregulation of long non… 
Review
2015
Review
2015
Disturbing the histone code in leukemia: translocations and mutations affecting histone methyl transferases.
2014
2014
Mitotic Accumulation of Dimethylated Lysine 79 of Histone H3 Is Important for Maintaining Genome Integrity During Mitosis in Human Cells
The loss of genome stability is an early event that drives the development and progression of virtually all tumor types. Recent… 
2014
2014
Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro
Primary acute myeloid leukemia cells with IDH1 or IDH2 mutations respond to a DOT1L inhibitor in vitro 
Review
2010
Review
2010
Targeting DOT1L action and interactions in leukemia: the role of DOT1L in transformation and development
Importance of the field: The establishment and maintenance of specialized chromatin is crucial for correct gene expression and… 
Review
2010
Review
2010
Histone H 2 B ubiquitination and beyond Regulation of nucleosome stability , chromatin dynamics and the trans-histone H 3 methylation
*Correspondence to: Zu-Wen Sun; Email: zuwen.sun@vanderbilt.edu Regulation of Set1-COMPASSmediated H3K4 methylation and Dot1… 
2009
2009
Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation
Understanding the mechanisms that link changes in DNA methylation with histone modifications is particularly relevant in the case… 
2003
2003
The Rtf 1 Component of the Paf 1 Transcriptional Elongation Complex Is Required for Ubiquitination of Histone H 2 B *
In yeast cells, the Rtf1 and Paf1 components of the Paf1 transcriptional elongation complex are important for recruitment of Set1… 
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