DOT1L gene

Known as: KMT4, DOT1L, DOT1 
This gene is involved in epigenetic control of gene expression.
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Little is known about how the immune system impacts human colorectal cancer invasiveness and stemness. Here we detected… (More)
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Highly Cited
2013
Highly Cited
2013
Rearrangements of the MLL gene define a genetically distinct subset of acute leukemias with poor prognosis. Current treatment… (More)
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Highly Cited
2013
Highly Cited
2013
Although recent studies have indicated roles of long non-coding RNAs (lncRNAs) in physiological aspects of cell-type… (More)
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Highly Cited
2012
Highly Cited
2012
Selective inhibition of protein methyltransferases is a promising new approach to drug discovery. An attractive strategy towards… (More)
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Highly Cited
2011
Highly Cited
2011
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing… (More)
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Highly Cited
2011
Highly Cited
2011
Mislocated enzymatic activity of DOT1L has been proposed as a driver of leukemogenesis in mixed lineage leukemia (MLL). The… (More)
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Highly Cited
2011
Highly Cited
2011
Chromosomal translocations of the mixed lineage leukemia (MLL) gene are a common cause of acute leukemias. The oncogenic function… (More)
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Highly Cited
2011
Highly Cited
2011
Disruptor of telomeric silencing 1-like (Dot1l) is a histone 3 lysine 79 methyltransferase. Studies of constitutive Dot1l… (More)
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Highly Cited
2008
Highly Cited
2008
The histone H3 lysine 79 methyltransferase DOT1L/KMT4 can promote an oncogenic pattern of gene expression through binding with… (More)
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Highly Cited
2008
Highly Cited
2008
Dot1 is an evolutionarily conserved histone methyltransferase specific for lysine 79 of histone H3 (H3K79). In Saccharomyces… (More)
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