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DOT1L gene

Known as: KMT4, DOT1L, DOT1 
This gene is involved in epigenetic control of gene expression.
National Institutes of Health

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DOT1L wt Allele
Gene ExpressionHistone-Lysine N-Methyltransferase H3 Lysine-79 Specific, HumanMethylationProtein methylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Histone modifications and their role in epigenetics of atopy and allergic diseases
This review covers basic aspects of histone modification and the role of posttranslational histone modifications in the… 
Highly Cited
2017
Highly Cited
2017
DOT1L safeguards cartilage homeostasis and protects against osteoarthritis
Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis… 
Highly Cited
2015
Highly Cited
2015
DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia
Rearrangements of MLL (encoding lysine-specific methyltransferase 2A and officially known as KMT2A; herein referred to as MLL to… 
Review
2013
Review
2013
To Wnt or not to Wnt: the bone and joint health dilemma
The Wnt signalling cascades have essential roles in development, growth and homeostasis of joints and the skeleton. Progress in… 
Highly Cited
2012
Highly Cited
2012
Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
Hip osteoarthritis (HOA) is one of the most disabling and common joint disorders with a large genetic component that is, however… 
Highly Cited
2011
Highly Cited
2011
DOT1L regulates dystrophin expression and is critical for cardiac function.
Histone methylation plays an important role in regulating gene expression. One such methylation occurs at Lys 79 of histone H3… 
Highly Cited
2011
Highly Cited
2011
Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein (DOT1L) Inhibits Cell Proliferation*
Background: DOT1L is responsible for methylation of histone H3K79. Results: DOT1L deficiency leads to senescence in lung cancer… 
Highly Cited
2009
Highly Cited
2009
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.
Highly Cited
2007
Highly Cited
2007
Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin.
Highly Cited
2005
Highly Cited
2005
Histone H2B ubiquitylation controls processive methylation but not monomethylation by Dot1 and Set1.
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