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Integration of External Signaling Pathways with the Core Transcriptional Network in Embryonic Stem Cells
Transcription factors (TFs) and their specific interactions with targets are crucial for specifying gene-expression programs. To gain insights into the transcriptional regulatory networks in… Expand
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
Oct4 and Nanog are transcription factors required to maintain the pluripotency and self-renewal of embryonic stem (ES) cells. Using the chromatin immunoprecipitation paired-end ditags method, we… Expand
Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
Cytosine residues in the sequence 5′CpG (cytosine–guanine) are often postsynthetically methylated in animal genomes. CpG methylation is involved in long-term silencing of certain genes during… Expand
Targeted recruitment of Set1 histone methylase by elongating Pol II provides a localized mark and memory of recent transcriptional activity.
Set1, the yeast histone H3-lysine 4 (H3-K4) methylase, is recruited by the Pol II elongation machinery to a highly localized domain at the 5' portion of active mRNA coding regions. Set1 association… Expand
Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation.
- Y. Zhang, H. Ng, H. Erdjument-Bromage, P. Tempst, A. Bird, D. Reinberg
- Biology, Medicine
- Genes & development
- 1 August 1999
ATP-dependent nucleosome remodeling and core histone acetylation and deacetylation represent mechanisms to alter nucleosome structure. NuRD is a multisubunit complex containing nucleosome remodeling… Expand
Transcriptional Regulation of Nanog by OCT4 and SOX2*
- D. Rodda, Joon-Lin Chew, +4 authors P. Robson
- Biology, Medicine
- Journal of Biological Chemistry
- 1 July 2005
Nanog, Sox2, and Oct4 are transcription factors all essential to maintaining the pluripotent embryonic stem cell phenotype. Through a cooperative interaction, Sox2 and Oct4 have previously been… Expand
A core Klf circuitry regulates self-renewal of embryonic stem cells
Embryonic stem (ES) cells are unique in their ability to self-renew indefinitely and maintain pluripotency. These properties require transcription factors that specify the gene expression programme… Expand
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
The ability to derive a whole-genome map of transcription-factor binding sites (TFBS) is crucial for elucidating gene regulatory networks. Herein, we describe a robust approach that couples chromatin… Expand
Transposable elements have rewired the core regulatory network of human embryonic stem cells
Detection of new genomic control elements is critical in understanding transcriptional regulatory networks in their entirety. We studied the genome-wide binding locations of three key regulatory… Expand
Human DNA-(cytosine-5) methyltransferase-PCNA complex as a target for p21WAF1.
DNA-(cytosine-5) methyltransferase (MCMT) methylates newly replicated mammalian DNA, but the factors regulating this activity are unknown. Here, MCMT is shown to bind proliferating cell nuclear… Expand