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Summary The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How this is accomplished is still… Expand Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome… Expand To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high… Expand Summary The firing of eukaryotic origins of DNA replication requires CDK and DDK kinase activities. DDK, in particular, is… Expand The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six… Expand Eukaryotic chromatin structure limits the initiation of DNA replication spatially to chromosomal origin zones and temporally to… Expand In early Xenopus development, transcription is repressed and DNA replication initiates at non-specific sites. Here, we show that… Expand We describe several new cloning vectors for mutagenesis and allele replacement experiments. These plasmids have the R6K gamma DNA… Expand Enzymatic synthesis of DNA from the simian virus 40 origin of DNA replication has been reconstituted in vitro with eight purified… Expand The region at and near the simian virus 40 (SV40) DNA replication origin contains a series of palindromes, a 17-base pair (bp) A… Expand