DNA replication origin
National Institutes of Health
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The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes…
Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome…
To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high…
Keeping Coordinated Before a cell divides, it must replicate its genome so that both daughter cells receive a copy of the…
Eukaryotic chromatin structure limits the initiation of DNA replication spatially to chromosomal origin zones and temporally to…
In early Xenopus development, transcription is repressed and DNA replication initiates at non-specific sites. Here, we show that…
We describe several new cloning vectors for mutagenesis and allele replacement experiments. These plasmids have the R6K gamma DNA…
DnaK is a major heat shock protein of Escherichia coli and the homolog of hsp70 in eukaryotes. We demonstrate the mechanism by…
Enzymatic synthesis of DNA from the simian virus 40 origin of DNA replication has been reconstituted in vitro with eight purified…