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DNA replication origin

National Institutes of Health

Papers overview

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Highly Cited
2018
Highly Cited
2018
The six-subunit origin recognition complex (ORC) binds to DNA to mark the site for the initiation of replication in eukaryotes… 
Highly Cited
2015
Highly Cited
2015
Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome… 
Highly Cited
2015
Highly Cited
2015
To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high… 
Highly Cited
2013
Highly Cited
2013
Keeping Coordinated Before a cell divides, it must replicate its genome so that both daughter cells receive a copy of the… 
Highly Cited
2005
Highly Cited
2005
Eukaryotic chromatin structure limits the initiation of DNA replication spatially to chromosomal origin zones and temporally to… 
Highly Cited
2004
Highly Cited
2004
In early Xenopus development, transcription is repressed and DNA replication initiates at non-specific sites. Here, we show that… 
Highly Cited
1996
Highly Cited
1996
We describe several new cloning vectors for mutagenesis and allele replacement experiments. These plasmids have the R6K gamma DNA… 
Highly Cited
1991
Highly Cited
1991
DnaK is a major heat shock protein of Escherichia coli and the homolog of hsp70 in eukaryotes. We demonstrate the mechanism by… 
Highly Cited
1990
Highly Cited
1990
Enzymatic synthesis of DNA from the simian virus 40 origin of DNA replication has been reconstituted in vitro with eight purified…