DNA replication origin

The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How this is accomplished is still poorly… (More)

Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome… (More)

The firing of eukaryotic origins of DNA replication requires CDK and DDK kinase activities. DDK, in particular, is involved in… (More)

Perturbation of DNA replication initiation arrests human cells in G1, pointing towards an origin activation checkpoint. We used… (More)

The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six… (More)

DNA replication in archaea and in eukaryotes share many similarities. We report the structure of an archaeal origin recognition… (More)

We have examined whether replication of the chicken beta-globin locus changes during differentiation of primary erythroid… (More)

Kinetoplast DNA, the mitochondrial DNA of trypanosomatids, is a remarkable DNA structure that contains, in the species Crithidia… (More)

In early Xenopus development, transcription is repressed and DNA replication initiates at non-specific sites. Here, we show that… (More)

Enzymatic synthesis of DNA from the simian virus 40 origin of DNA replication has been reconstituted in vitro with eight purified… (More)