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DNA replication origin

National Institutes of Health

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Broader (1)

DNA Replication
DNA Replication Forkautonomously replicating sequencereplicator

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates
Summary The integrity of eukaryotic genomes requires rapid and regulated chromatin replication. How this is accomplished is still… Expand
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Highly Cited
2015
Highly Cited
2015
Regulated Eukaryotic DNA Replication Origin Firing with Purified Proteins
Eukaryotic cells initiate DNA replication from multiple origins, which must be tightly regulated to promote precise genome… Expand
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Highly Cited
2015
Highly Cited
2015
The chromatin environment shapes DNA replication origin organization and defines origin classes.
To unveil the still-elusive nature of metazoan replication origins, we identified them genome-wide and at unprecedented high… Expand
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Highly Cited
2014
Highly Cited
2014
Protein Phosphatase 1 Recruitment by Rif1 Regulates DNA Replication Origin Firing by Counteracting DDK Activity
Summary The firing of eukaryotic origins of DNA replication requires CDK and DDK kinase activities. DDK, in particular, is… Expand
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Highly Cited
2009
Highly Cited
2009
Concerted Loading of Mcm2–7 Double Hexamers around DNA during DNA Replication Origin Licensing
The licensing of eukaryotic DNA replication origins, which ensures once-per-cell-cycle replication, involves the loading of six… Expand
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Highly Cited
2005
Highly Cited
2005
The histone deacetylase inhibitor trichostatin A alters the pattern of DNA replication origin activity in human cells
Eukaryotic chromatin structure limits the initiation of DNA replication spatially to chromosomal origin zones and temporally to… Expand
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Highly Cited
2004
Highly Cited
2004
Specification of a DNA replication origin by a transcription complex
In early Xenopus development, transcription is repressed and DNA replication initiates at non-specific sites. Here, we show that… Expand
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Highly Cited
1996
Highly Cited
1996
Conditionally replicative and conjugative plasmids carrying lacZ alpha for cloning, mutagenesis, and allele replacement in bacteria.
We describe several new cloning vectors for mutagenesis and allele replacement experiments. These plasmids have the R6K gamma DNA… Expand
Highly Cited
1990
Highly Cited
1990
Sequential initiation of lagging and leading strand synthesis by two different polymerase complexes at the SV40 DNA replication origin
Enzymatic synthesis of DNA from the simian virus 40 origin of DNA replication has been reconstituted in vitro with eight purified… Expand
Highly Cited
1982
Highly Cited
1982
Territorial limits and functional anatomy of the simian virus 40 replication origin.
The region at and near the simian virus 40 (SV40) DNA replication origin contains a series of palindromes, a 17-base pair (bp) A… Expand
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