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Comparative assessment of large-scale data sets of protein–protein interactions
TLDR
Comprehensive protein–protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function and are compared with each other and with a reference set of previously reported protein interactions. Expand
Life with 6000 Genes
TLDR
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration and provides information about the higher order organization of yeast's 16 chromosomes and allows some insight into their evolutionary history. Expand
Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
TLDR
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid, and the sequenced genome revealed a large number of major facilitator superfamily transporters and fungal zinc binuclear cluster transcription factors. Expand
Mapping pathways and phenotypes by systematic gene overexpression.
TLDR
Overexpression of most toxic genes resulted in phenotypes different from known deletion mutant phenotypes, suggesting that overexpression phenotypes usually reflect a specific regulatory imbalance rather than disruption of protein complex stoichiometry. Expand
A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
TLDR
It is demonstrated how the intracellular concentrations of metabolites can reveal phenotypes for proteins active in metabolic regulation, and this approach to functional analysis, using comparative metabolomics, is called FANCY—an abbreviation for functional analysis by co-responses in yeast. Expand
PomBase: a comprehensive online resource for fission yeast
TLDR
The implementation of PomBase integrates a Chado relational database that houses manually curated data with Ensembl software that supports sequence-based annotation and web access and will provide user-friendly tools to promote curation by experts within the fission yeast community. Expand
Dynamics of Protein Turnover, a Missing Dimension in Proteomics*
TLDR
Stable isotope-labeled amino acids can be used to define the rate of breakdown of individual proteins by inspection of mass shifts in tryptic fragments and this approach has been applied to an analysis of abundant proteins in glucose-limited yeast cells grown in aerobic chemostat culture at steady state. Expand
High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
TLDR
It is shown that metabolic footprinting is an effective method to classify 'unknown' mutants by genetic defect by using appropriate clustering and machine learning techniques, the latter based on genetic programming. Expand
Dispersed growth of Streptomyces in liquid culture
TLDR
Improvements in both biomass yield and product yield of the pigmented antibiotic actinorhodin were found to result from the incorporation of Junlon into minimal medium. Expand
The Gene Ontology Resource: 20 years and still GOing strong
TLDR
GO-CAM, a new framework for representing gene function that is more expressive than standard GO annotations, has been released, and users can now explore the growing repository of these models. Expand
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