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Comparative assessment of large-scale data sets of protein–protein interactions
Comprehensive protein–protein interaction maps promise to reveal many aspects of the complex regulatory network underlying cellular function. Recently, large-scale approaches have predicted many newExpand
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Life with 6000 Genes
The genome of the yeast Saccharomyces cerevisiae has been completely sequenced through a worldwide collaboration. The sequence of 12,068 kilobases defines 5885 potential protein-encoding genes,Expand
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Genome sequencing and analysis of the versatile cell factory Aspergillus niger CBS 513.88
The filamentous fungus Aspergillus niger is widely exploited by the fermentation industry for the production of enzymes and organic acids, particularly citric acid. We sequenced the 33.9-megabaseExpand
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Mapping pathways and phenotypes by systematic gene overexpression.
Many disease states result from gene overexpression, often in a specific genetic context. To explore gene overexpression phenotypes systematically, we assembled an array of 5280 yeast strains, eachExpand
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A functional genomics strategy that uses metabolome data to reveal the phenotype of silent mutations
A large proportion of the 6,000 genes present in the genome of Saccharomyces cerevisiae, and of those sequenced in other organisms, encode proteins of unknown function. Many of these genes areExpand
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PomBase: a comprehensive online resource for fission yeast
PomBase (www.pombase.org) is a new model organism database established to provide access to comprehensive, accurate, and up-to-date molecular data and biological information for the fission yeastExpand
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Functional genomic hypothesis generation and experimentation by a robot scientist
The question of whether it is possible to automate the scientific process is of both great theoretical interest and increasing practical importance because, in many scientific areas, data are beingExpand
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Dynamics of Protein Turnover, a Missing Dimension in Proteomics*
Functional genomic experiments frequently involve a comparison of the levels of gene expression between two or more genetic, developmental, or physiological states. Such comparisons can be carriedExpand
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High-throughput classification of yeast mutants for functional genomics using metabolic footprinting
Many technologies have been developed to help explain the function of genes discovered by systematic genome sequencing. At present, transcriptome and proteome studies dominate large-scale functionalExpand
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Dispersed growth of Streptomyces in liquid culture
SummaryThe study of the physiology of the filamentous bacterium Streptomyces is inhibited by its formation of mycelial pellets in liquid cultures. It is demonstrated that dispersed growth may beExpand
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