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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Routine molecular profiling of patients with advanced non-small-cell lung cancer: results of a 1-year nationwide programme of the French Cooperative Thoracic Intergroup (IFCT)
The frequency of genetic alterations, acceptable turnaround times in obtaining analysis results, and the clinical advantage provided by detection of a genetic alteration suggest that this nationwide molecular profiling of patients with advanced NSCLC provides a clinical benefit. Expand
Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolization.
PVE allows more patients with previously unresectable liver tumors to benefit from resection, and long-term survival is comparable to that after resection without PVE. Expand
Progression of Alphafetoprotein Before Liver Transplantation for Hepatocellular Carcinoma in Cirrhotic Patients: A Critical Factor
- E. Vibert, D. Azoulay, +7 authors R. Adam
- American journal of transplantation : official…
- 1 January 2010
Increasing AFP >15 μg/L/month while waiting for LT is the most relevant preoperative prognostic factor for low OS/DFS. Expand
Percutaneous Portal Vein Embolization Increases the Feasibility and Safety of Major Liver Resection for Hepatocellular Carcinoma in Injured Liver
With the use of PVE, more patients with previously unresectable HCC in injured liver can benefit from resection, and long-term survival rates are comparable to those after resection without PVE. Expand
Functions of autophagy in normal and diseased liver
This review summarizes recent advances in understanding the roles that autophagy plays in normal hepatic physiology and pathophysiology with the intent of furthering the development of autophileagy-based therapies for human liver diseases. Expand
Decision for Retransplantation of the Liver: An Experience- and Cost-Based Analysis
The utility of retransplantation in the elective situation is confirmed and should be used with discretion in the emergency setting, and it should be avoided in subgroups of patients with little chance of success. Expand
Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis.
The EGF gene polymorphism genotype is associated with risk for development of hepatocellular carcinoma in liver cirrhosis through modulation of EGF levels through inhibition fragment-length polymorphism. Expand
Stage II colon cancer prognosis prediction by tumor gene expression profiling.
- A. Barrier, P. Boelle, +10 authors S. Dudoit
- Journal of clinical oncology : official journal…
- 10 October 2006
Microarray gene expression profiling is able to predict the prognosis of stage II colon cancer patients and illustrates the usefulness of resampling techniques for honest performance assessment of microarray-based PPs. Expand
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.
P-450 1A2 and P-450 3A4 are the major enzymes involved in imipramine N-demethylation in human hepatic microsomes, and these results suggest that interindividual variations in3A4 hepatic content may explain the large variations in imIPramine blood levels observed after uniform dosages and thus explain the variations in clinical efficacy. Expand