DNA Topoisomerases

Known as: DNA Topoisomerases [Chemical/Ingredient], Topoisomerases, DNA 
Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are… (More)
National Institutes of Health

Papers overview

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Review
2004
Review
2004
Topoisomerases are enzymes that use DNA strand scission, manipulation, and rejoining activities to directly modulate DNA topology… (More)
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Review
2003
Review
2003
Type II DNA topoisomerases (Topo II) are essential enzymes implicated in key nuclear processes. The recent discovery of a novel… (More)
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Highly Cited
2001
Highly Cited
2001
Type II DNA topoisomerases actively reduce the fractions of knotted and catenated circular DNA below thermodynamic equilibrium… (More)
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Highly Cited
2000
Highly Cited
2000
Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand… (More)
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Highly Cited
1997
Highly Cited
1997
Type II DNA topoisomerases catalyze the interconversion of DNA topoisomers by transporting one DNA segment through another. The… (More)
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Highly Cited
1989
Highly Cited
1989
We have examined the roles of eukaryotic DNA topoisomerases I and II in DNA replication by the use of a set of four isogenic… (More)
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Highly Cited
1981
Highly Cited
1981
Two type I DNA topoisomerases have been purified to homogeneity from the nuclei of HeLa cells. One topoisomerase has a peptide… (More)
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Highly Cited
1981
Highly Cited
1981
DNA molecules isolated from bacteriophage P4 are mostly linear with cohesive ends capable of forming circular and concatemeric… (More)
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Highly Cited
1980
Highly Cited
1980
The T4 DNA topoisomerase is a recently discovered multisubunit protein that appears to have an essential role in the initiation… (More)
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Highly Cited
1980
Highly Cited
1980
The cleavage of a DNA phosphodiester bond by Escherichia coli DNA topoisomerase I and the simultaneous covalent linkage of the… (More)
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