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DNA Topoisomerases

Known as: DNA Topoisomerases [Chemical/Ingredient], Topoisomerases, DNA 
Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are… 
National Institutes of Health

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DNA Topoisomerases, Type I
In BloodProcess of secretionaspects of radiation effectschemical synthesis

Papers overview

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2007
2007
Dissection of the nucleotide cycle of B. subtilis DNA gyrase and its modulation by DNA.
1999
1999
Relating structure to function through the dominant slow modes of motion of DNA topoisomerase II
Type II DNA topoisomerases are enzymes capable of transporting one DNA duplex through another by performing a cycle of DNA… 
1999
1999
Kinetic and Thermodynamic Analysis of Mutant Type II DNA Topoisomerases That Cannot Covalently Cleave DNA*
DNA topoisomerase II catalyzes two different chemical reactions as part of its DNA transport cycle: ATP hydrolysis and DNA… 
1996
1996
Structure and conformational changes of DNA topoisomerase II visualized by electron microscopy.
Type II DNA topoisomerases, which create a transient gate in duplex DNA and transfer a second duplex DNA through this gate, are… 
1990
1990
Archaebacterial reverse gyrase cleavage-site specificity is similar to that of eubacterial DNA topoisomerases I.
ATP-dependent type I topoisomerases from extremely thermophilic archaebacteria--reverse gyrases--drive positive supercoiling of… 
Review
1988
Review
1988
DNA topoisomerases as targets for chemotherapy
DNA topoisomerases are ubiquitous enzymes that alter the configuration or topology of DNA. These enzymes play an important role… 
Highly Cited
1986
Highly Cited
1986
Characterization of acquired epipodophyllotoxin resistance in a Chinese hamster ovary cell line: loss of drug-stimulated DNA cleavage activity.
Recent evidence indicates that type II DNA topoisomerases mediate epipodophyllotoxin-induced DNA damage and may be intrinsic to… 
Highly Cited
1984
Highly Cited
1984
Virus- and cell-encoded tyrosine protein kinases inactivate DNA topoisomerases in vitro
Tyrosine protein kinase activity is associated with at least eight different retrovirus-encoded onc gene products1 and with cell… 
Highly Cited
1982
Highly Cited
1982
Yeast DNA topoisomerase II. An ATP-dependent type II topoisomerase that catalyzes the catenation, decatenation, unknotting, and relaxation of double-stranded DNA rings.
An activity from the yeast Saccharomyces cerevisiae, initially noted for its catalysis of aggregation of covalently closed double… 
Review
1981
Review
1981
Proteins controlling the helical structure of DNA.
AND PERSPECTIVES… 
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