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Comparative genomics of the lactic acid bacteria
Phylogenetic analyses, comparison of gene content across the group, and reconstruction of ancestral gene sets indicate a combination of extensive gene loss and key gene acquisitions via horizontal gene transfer during the coevolution of lactic acid bacteria with their habitats.
The complete genome of hyperthermophile Methanopyrus kandleri AV19 and monophyly of archaeal methanogens
The complete sequence of the GC-rich genome of Methanopyrus kandleri is determined by using a whole direct genome sequencing approach and indicates that archaeal methanogens are monophyletic.
An ancestral nuclear protein assembly: Crystal structure of the Methanopyrus kandleri histone
It is inferred that the Methanopyrus histone binds DNA in a manner similar to the eukaryotic histone tetramer [H3–H4]2, based on the spatial similarities to structural ms found in the eUKaryotic nucleosome that are important for DNA‐binding.
The Domain Organization and Properties of Individual Domains of DNA Topoisomerase V, a Type 1B Topoisomerase with DNA Repair Activities*
Topo V has at least two active sites capable of processing AP DNA, and it is demonstrated that Topo78 and Topo34 possess AP lyase activities that are important in base excision DNA repair.
DNA topoisomerase V is a relative of eukaryotic topoisomerase I from a hyperthermophilic prokaryote
The findings support the idea that some essential parts of the eukaryotic transcription–translation and replication machineries were in place before the emergence of eukARYotes, and that the closest living relatives of eUKaryotes may be hyperthermophiles.
A type IB topoisomerase with DNA repair activities
Topo V is the prototype for a new subfamily of type IB topoisomersases and is the first example of a topoisomerase with associated DNA repair activities.
Helix–hairpin–helix motifs confer salt resistance and processivity on chimeric DNA polymerases
The approach to raise the salt tolerance, processivity, and thermostability of Taq and Pfu DNA polymerases may be applied to all pol1- and polB-type polymerases, as well as to other DNA processing enzymes.