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DNA Primase

Known as: DNA Primase [Chemical/Ingredient], Primase, Primase, DNA 
Heterodimeric human DNA Primase consists of a 49-kDa (small) and a 58-kDa (large) subunit. Eukaryotic DNA replication involves a replication… 
National Institutes of Health

Related topics

Related topics

21 relations
Bacteriophage T7 Gene 4 ProteinDNA ReplicationDNA primase activityDNA-Directed RNA Polymerase

Narrower (4)

PRIM1 protein, humanPrimPol protein, humandnaG protein, E colihelicase-primase, Human herpesvirus 1

Broader (2)

RNA Nucleotidyltransferasesnucleotidyltransferase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1997
Highly Cited
1997
Inhibition of DNA primase by sphingosine and its analogues parallels with their growth suppression of cultured human leukemic cells
Sphingosine is a potent inhibitor of a mammalian DNA primase in vitro (Simbulan et al., Biochemistry 33, 9007‐9012, 1994). Here… 
Highly Cited
1997
Highly Cited
1997
The poison–antidote stability system of the broad‐host‐range Thiobacillus ferrooxidans plasmid pTF‐FC2
In plasmid pTF‐FC2, three small open reading frames (ORFs) are situated between the repB (primase) gene and the repA (helicase… 
Highly Cited
1997
Highly Cited
1997
Characterization and crystallization of the helicase domain of bacteriophage T7 gene 4 protein
Limited proteolysis of bacteriophage T7 primase/helicase with endoproteinase Glu-C produces several proteolytic fragments. One of… 
Highly Cited
1996
Highly Cited
1996
Biochemical Analysis of Mutant T7 Primase/Helicase Proteins Defective in DNA Binding, Nucleotide Hydrolysis, and the Coupling of Hydrolysis with DNA Unwinding*
We characterized nine helicase-deficient mutants of bacteriophage T7 helicase-primase protein (4A′) prepared by random… 
Highly Cited
1994
Highly Cited
1994
Analysis of cis and trans acting elements required for the initiation of DNA replication in the Bacillus subtilis bacteriophage SPP1.
Highly Cited
1993
Highly Cited
1993
Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.
Different pri1 and pri2 conditional mutants of Saccharomyces cerevisiae altered, respectively, in the small (p48) and large (p58… 
Highly Cited
1991
Highly Cited
1991
Requirements for primer synthesis by bacteriophage T7 63-kDa gene 4 protein. Roles of template sequence and T7 56-kDa gene 4 protein.
1988
1988
Purification of the 56-kDa component of the bacteriophage T7 primase/helicase and characterization of its nucleoside 5'-triphosphatase activity.
Highly Cited
1981
Highly Cited
1981
A plasmid DNA primase active in discontinuous bacterial DNA replication
A DNA primase encoded by an IncIα plasmid promotes efficient DNA replication in a primase-defective mutant of Escherichia coli… 
Highly Cited
1977
Highly Cited
1977
Role of bacteriophage T7 DNA primase in the initiation of DNA strand synthesis.
Bacteriophage T7 DNA primase (gene-4 protein, 66,000 daltons) enables T7 DNA polymerase to initiate the synthesis of DNA chains… 
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