DNA Mismatch Repair Protein PMS1
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Recombination between moderately divergent DNA sequences is impaired compared with identical sequences. In yeast, an HO… Expand DNA mismatch repair is important because of its role in maintaining genomic integrity and its association with hereditary non… Expand Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2… Expand The yeast genome encodes four proteins (Pms1 and Mlh1-3) homologous to the bacterial mismatch repair component, MutL. Using two… Expand Germline mutations in the human MSH2, MLH1, PMS2 and PMS1 DNA mismatch repair (MMR) gene homologues appear to be responsible for… Expand The Saccharomyces cerevisiae genome encodes four MutL homologs. Of these, MLH1 and PMS1 are known to act in the MSH2-dependent… Expand The mismatch repair system is the major barrier to genetic recombination during interspecific sexual conjugation in prokaryotes… Expand The discovery that mutations in DNA mismatch repair genes can cause hereditary nonpolyposis colorectal cancer has stimulated… Expand We have identified a new Saccharomyces cerevisiae gene, MLH1 (mutL homolog), that encodes a predicted protein product with… Expand Mutation of predicted 3′‐‐>5′ exonuclease active site residues of Saccharomyces cerevisiae POL3 DNA polymerase (delta) or… Expand