DNA Mismatch Repair Protein PMS1

ABSTRACT Drug resistance has become a major problem in the treatment of Candida albicans infections. Genome changes, such as… Expand

Recombination between moderately divergent DNA sequences is impaired compared with identical sequences. In yeast, an HO… Expand

ABSTRACT EXO1 interacts with MSH2 and MLH1 and has been proposed to be a redundant exonuclease that functions in mismatch repair… Expand

DNA mismatch repair is important because of its role in maintaining genomic integrity and its association with hereditary non… Expand

Eukaryotic mismatch repair (MMR) has been shown to require two different heterodimeric complexes of MutS-related proteins: MSH2… Expand

Germline mutations in the human MSH2, MLH1, PMS2 and PMS1 DNA mismatch repair (MMR) gene homologues appear to be responsible for… Expand

The mismatch repair system is the major barrier to genetic recombination during interspecific sexual conjugation in prokaryotes… Expand

Efficient genetic recombination requires near-perfect homology between participating molecules. Sequence divergence reduces the… Expand

The discovery that mutations in DNA mismatch repair genes can cause hereditary nonpolyposis colorectal cancer has stimulated… Expand

We have identified a new Saccharomyces cerevisiae gene, MLH1 (mutL homolog), that encodes a predicted protein product with… Expand