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DNA Methyltransferase Inhibitors [MoA]

Known as: DNA Methyltransferase Inhibitors, DNA Methytransferase Inhibitors 
 

Topic mentions per year

Topic mentions per year

2011-2017
024620112017

Related topics

Related topics

2 relations
AzacitidineDNA Methyltransferase Inhibitor

Related mentions per year

Related mentions per year

1964-2018
1960198020002020
DNA Methyltransferase Inhibitors [MoA]
Azacitidine
DNA Methyltransferase Inhibitor

Papers overview

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2017
2017
Epigenetically Aberrant Stroma in MDS Propagates Disease via Wnt/b-Catenin Activation
The bone marrow microenvironment influences malignant hematopoiesis, but how it promotes leukemogenesis has not been elucidated… (More)
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2016
2016
The failure of epigenetic combination therapy for cancer and what it might be telling us about DNA methylation inhibitors.
Epigenetic changes in cancer are well described, and it is believed aberrant DNA hypermethylation and histone deacetylation can… (More)
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2015
2015
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic… (More)
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2015
2015
The combination of hypomethylating agents and histone deacetylase inhibitors produce marked synergy in preclinical models of T-cell lymphoma.
T-cell lymphomas (TCL) are aggressive lymphomas usually treated with CHOP (cyclophsophamide, doxorubicin, vincristine… (More)
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2015
2015
Computational fishing of new DNA methyltransferase inhibitors from natural products.
DNA methyltransferase inhibitors (DNMTis) have become an alternative for cancer therapies. However, only two DNMTis have been… (More)
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2014
2014
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Different epigenetic alterations (DNA methylation, histone modifications, chromatin remodeling, noncoding RNA dysregulation) are… (More)
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2014
2014
The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma
DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi) are under investigation for the treatment of… (More)
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2013
2013
Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells.
Epigenetic alterations are a hallmark of cancer that govern the silencing of genes. Up to now, 5-azacytidine (5-aza-CR, Vidaza… (More)
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2013
2013
Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines.
DNA methyltransferase inhibitors (DNMTIs), including decitabine (DAC) and azacitidine (AZA), have recently been highlighted for… (More)
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2013
2013
Epigenetics: Showing a more sensitive side
 
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