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DNA Methyltransferase Inhibitors [MoA]

Known as: DNA Methyltransferase Inhibitors, DNA Methytransferase Inhibitors 
 
National Institutes of Health

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2 relations
AzacitidineDNA Methyltransferase Inhibitor

Papers overview

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Highly Cited
2016
Highly Cited
2016
Vitamin C increases viral mimicry induced by 5-aza-2'-deoxycytidine.
Vitamin C deficiency is found in patients with cancer and might complicate various therapy paradigms. Here we show how this… Expand
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Highly Cited
2015
Highly Cited
2015
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses
We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway… Expand
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Highly Cited
2015
Highly Cited
2015
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
We show that DNA methyltransferase inhibitors (DNMTis) upregulate immune signaling in cancer through the viral defense pathway… Expand
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Highly Cited
2015
Highly Cited
2015
Specific molecular signatures predict decitabine response in chronic myelomonocytic leukemia.
Myelodysplastic syndromes and chronic myelomonocytic leukemia (CMML) are characterized by mutations in genes encoding epigenetic… Expand
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2015
2015
Presence of isocitrate dehydrogenase mutations may predict clinical response to hypomethylating agents in patients with acute myeloid leukemia.
Mutations in IDH1 and IDH2 occur in 15-20% of AML cases, resulting in the production of 2-hydroxyglutarate, which promotes… Expand
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2014
2014
Epigenomic networking in drug development: from pathogenic mechanisms to pharmacogenomics.
Different epigenetic alterations (DNA methylation, histone modifications, chromatin remodeling, noncoding RNA dysregulation) are… Expand
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2014
2014
The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma
DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi) are under investigation for the treatment of… Expand
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2013
2013
Differential induction of apoptosis and senescence by the DNA methyltransferase inhibitors 5-azacytidine and 5-aza-2'-deoxycytidine in solid tumor cells.
Epigenetic alterations are a hallmark of cancer that govern the silencing of genes. Up to now, 5-azacytidine (5-aza-CR, Vidaza… Expand
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2011
2011
GSTP1 DNA Methylation and Expression Status Is Indicative of 5-aza-2′-Deoxycytidine Efficacy in Human Prostate Cancer Cells
DNA methylation plays an important role in carcinogenesis and the reversibility of this epigenetic modification makes it a… Expand
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2011
2011
Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
Background:Epigenetic mechanisms have important roles in the tumour escape from immune responses, such as in MHC class I… Expand
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