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Genomic landscape of cutaneous T cell lymphoma
TLDR
The results implicate mutations in 17 genes in CTCL pathogenesis, including genes involved in T cell activation and apoptosis, NF-κB signaling, chromatin remodeling and DNA damage response, which have implications for new therapeutics. Expand
Romidepsin for the Treatment of Peripheral T-Cell Lymphoma
TLDR
An overview of PTCL is provided, the role of HDAC inhibitors as anticancer agents are reviewed, romidepsin use in P TCL is discussed, and considerations for advanced practitioners are highlighted (including the management of side effects). Expand
The clinical use of DNA methyltransferase inhibitors in myelodysplastic syndromes
TLDR
The clinical use of DNMTIs in MDS was one of the earliest successful attempts at epigenetic reprogramming of cancer, highlighting the current challenges and controversies and future directions of research needed to explore the full therapeutic potential of these agents. Expand
Patterns of Venous Thromboembolism Prophylaxis During Treatment of Acute Leukemia: Results of a North American Web-Based Survey.
TLDR
Large, prospective studies are needed to define the safest and most effective approach to VTE prevention in patients with AL during induction and consolidation therapies. Expand
The Society for Immunotherapy of Cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: multiple myeloma, lymphoma, and acute leukemia
Increasing knowledge concerning the biology of hematologic malignancies as well as the role of the immune system in the control of these diseases has led to the development and approval ofExpand
Wide variations in blood product transfusion practices among providers who care for patients with acute leukemia in the United States
TLDR
The primary objective of this study was to determine the spectrum of transfusion patterns in a variety of care settings among providers who treat AL patients. Expand
Pilot study of sorafenib in relapsed or refractory peripheral and cutaneous T‐cell lymphoma
TLDR
It is hypothesized that sorafenib may have significant clinical activity in lymphoma patients by blocking signalling through PDGFR as well as VEGFR, and the potential therapeutic benefit of targeting these pathways is hypothesized. Expand
The Interactions Between Diabetes Mellitus and Myelodysplastic Syndromes: Current State of Evidence and Future Directions.
TLDR
Current knowledge of the interactions between DM and MDS is reviewed at the pathogenetic, clinical and epidemiologic levels, discuss how this knowledge could be used therapeutically to improve the outcome of patients affected by both conditions, and delineate important unmet needs that should be addressed in future research. Expand
A Pilot Study Of Sorafenib In Refractory Or Relapsed T-Cell Lymphoma Patients
TLDR
In this pilot study, sorafenib demonstrated activity in pts with refractory T-cell lymphomas but dose modifications for skin toxicity occurred frequently, suggesting that a lower dose would be more tolerable. Expand
Development of a policy and procedure for accidental chemotherapy overdose.
TLDR
A policy regarding rapid response to chemotherapy overdoses was developed by the authors in an attempt to minimize morbidity and mortality and the availability of a chemotherapy overdose policy provides an enhanced level of safety for patients. Expand
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