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DNA Gyrase

Known as: DNA Gyrase [Chemical/Ingredient], DNA-Gyrase 
A bacterial DNA topoisomerase II that catalyzes ATP-dependent breakage of both strands of DNA, passage of the unbroken strands through the breaks… 
National Institutes of Health

Related topics

Related topics

10 relations

Narrower (2)

DNA Gyrase A SubunitDNA Gyrase B Subunit
In BloodProcess of secretionaspects of radiation effectschemical synthesis

Broader (2)

IsomeraseTopoisomerase II

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases.
Highly Cited
2007
Highly Cited
2007
Discovery of Novel DNA Gyrase Inhibitors by High-Throughput Virtual Screening
ABSTRACT The bacterial type II topoisomerases DNA gyrase and topoisomerase IV are validated targets for clinically useful… 
Review
1996
Review
1996
Molecular mechanisms of durg inhibition of DNA gyrase
DNA gyrase, an enzyme unique to prokaryotes, has been implicated in almost all processes that involve DNA. Although efficient… 
1994
1994
Placement of alkyl substituents on the C-7 piperazine ring of fluoroquinolones: dramatic differential effects on mammalian topoisomerase II and DNA gyrase
Several substituted analogs of 7-(cis-3,5-dimethylpiperazinyl)-6,8-difluoro-5-amino-1-cyclopropyl quinolone were prepared and… 
Highly Cited
1993
Highly Cited
1993
Biological characterization of cyclothialidine, a new DNA gyrase inhibitor
Cyclothialidine is a new DNA gyrase inhibitor isolated from Streptomyces filipinensis NR0484. Structurally, it belongs to a new… 
Highly Cited
1991
Highly Cited
1991
Novel quinolone resistance mutations of the Escherichia coli DNA gyrase A protein: enzymatic analysis of the mutant proteins
Using the techniques of gap misrepair mutagenesis and site-directed mutagenesis, we have generated two novel quinolone resistance… 
Highly Cited
1989
Highly Cited
1989
Structure of the Drosophila DNA topoisomerase II gene. Nucleotide sequence and homology among topoisomerases II.
Highly Cited
1989
Highly Cited
1989
Nuclease protection by Drosophila DNA topoisomerase II. Enzyme/DNA contacts at the strong topoisomerase II cleavage sites.
A DNA consensus sequence for topoisomerase II cleavage sites was derived previously based on a statistical analysis of the… 
Highly Cited
1982
Highly Cited
1982
Antagonism of the B subunit of DNA gyrase eliminates plasmids pBR322 and pMG110 from Escherichia coli
The constructed plasmid pBR322 and the native plasmid pMG110 were eliminated (cured) from growing Escherichia coli cells by the… 
Highly Cited
1981
Highly Cited
1981
Dependence of mammalian DNA synthesis on DNA supercoiling. III. Characterization of the inhibition of replicative and repair-type DNA synthesis by novobiocin and nalidixic acid.
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