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DDD 85646
Known as:
DDD-85646
, DDD85646
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Aminopyridines
Sulfonamides
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases
W. Kallemeijn
,
Gregor A. Lueg
,
+6 authors
Edward W. Tate
Cell Chemical Biology
2019
Corpus ID: 128167126
2017
2017
Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors
T. Bayliss
,
D. Robinson
,
+11 authors
P. Wyatt
Journal of Medicinal Chemistry
2017
Corpus ID: 8960205
N-Myristoyltransferase (NMT) represents a promising drug target within the parasitic protozoa Trypanosoma brucei (T. brucei), the…
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2016
2016
The N-myristoylome of Trypanosoma cruzi
A. Roberts
,
A. Fairlamb
Scientific Reports
2016
Corpus ID: 4854293
Protein N-myristoylation is catalysed by N-myristoyltransferase (NMT), an essential and druggable target in Trypanosoma cruzi…
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2015
2015
Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase
D. Robinson
,
P. Wyatt
Acta Crystallographica Section F Structural…
2015
Corpus ID: 7350988
N-Myristoyltransferase (NMT) has been shown to be an attractive target for the development of novel therapeutic agents for the…
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Highly Cited
2014
Highly Cited
2014
Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2…
S. Brand
,
Neil R. Norcross
,
+18 authors
K. Read
Journal of Medicinal Chemistry
2014
Corpus ID: 13121398
Trypanosoma bruceiN-myristoyltransferase (TbNMT) is an attractive therapeutic target for the treatment of human African…
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2014
2014
Biochemical and genetic characterization of Trypanosoma cruzi N-myristoyltransferase
A. Roberts
,
L. S. Torrie
,
S. Wyllie
,
A. Fairlamb
Biochemical Journal
2014
Corpus ID: 15602586
Co- and post-translational N-myristoylation is known to play a role in the correct subcellular localization of specific proteins…
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2014
2014
Drug Target Identification Using a Trypanosome Overexpression Library
Daniela Begolo
,
E. Erben
,
C. Clayton
Antimicrobial Agents and Chemotherapy
2014
Corpus ID: 30646049
ABSTRACT Elucidation of molecular targets is very important for lead optimization during the drug development process. We…
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2014
2014
Using a Non-Image-Based Medium-Throughput Assay for Screening Compounds Targeting N-myristoylation in Intracellular Leishmania Amastigotes
Daniel Paape
,
A. Bell
,
+4 authors
Deborah F. Smith
PLoS Neglected Tropical Diseases
2014
Corpus ID: 14831417
We have refined a medium-throughput assay to screen hit compounds for activity against N-myristoylation in intracellular…
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Highly Cited
2011
Highly Cited
2011
Discovery of a Novel Class of Orally Active Trypanocidal N-Myristoyltransferase Inhibitors
S. Brand
,
Laura A. T. Cleghorn
,
+17 authors
I. Gilbert
Journal of Medicinal Chemistry
2011
Corpus ID: 3180167
N-Myristoyltransferase (NMT) represents a promising drug target for human African trypanosomiasis (HAT), which is caused by the…
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