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The Genome of the Kinetoplastid Parasite, Leishmania major
TLDR
The organization of protein-coding genes into long, strand-specific, polycistronic clusters and lack of general transcription factors in the L. major, Trypanosoma brucei, and Tritryp genomes suggest that the mechanisms regulating RNA polymerase II–directed transcription are distinct from those operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling.
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Life without transcriptional control? From fly to man and back again
TLDR
The organisms concerned are unicellular, spindle‐ like flagellates that flourish in the digestive systems of arthropods, in the blood, macrophages and brains of vertebrates from humans to lizards, and even in the sap of coconut palms and lemon trees.
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Post-transcriptional regulation of gene expression in trypanosomes and leishmanias.
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Vectors for inducible expression of toxic gene products in bloodstream and procyclic Trypanosoma brucei.
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Inducible gene expression in trypanosomes mediated by a prokaryotic repressor.
TLDR
An inducible expression system was developed for the protozoan parasite Trypanosoma brucei that exhibited inducer (tetracycline)-dependent expression of chromosomally integrated reporter genes under the control of a procyclic acidic repetitive protein (PARP) promoter bearing a tet operator.
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Heat shock causes a decrease in polysomes and the appearance of stress granules in trypanosomes independently of eIF2α phosphorylation at Thr169
In trypanosomes there is an almost total reliance on post-transcriptional mechanisms to alter gene expression; here, heat shock was used to investigate the response to an environmental signal. Heat…
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The promoter for a variant surface glycoprotein gene expression site in Trypanosoma brucei.
TLDR
It is shown that the activity of this expression site is controlled at or near transcription initiation in bloodstream trypanosomes, including mechanisms of promoter inactivation involving DNA rearrangements in the vicinity of the transcription start site.
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The exosome of Trypanosoma brucei
TLDR
It is shown that the unicellular parasite Trypanosoma brucei contains at least eight exosome subunit homologs, but only a subset of these associate in a complex, suggesting that the T.brucei Exosome is smaller than that of yeast.
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A role for Caf1 in mRNA deadenylation and decay in trypanosomes and human cells
TLDR
The roles of Ccr4 and Caf1 in deadenylation in two organisms that separated early in eukaryotic evolution: humans and trypanosomes are investigated.
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A doubly inducible system for RNA interference and rapid RNAi plasmid construction in Trypanosoma brucei.
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