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DARC protein, human

Known as: CD234 Antigen, FY protein, human, Duffy blood group-associated glycoprotein D, human 
Atypical chemokine receptor 1 (336 aa, ~36 kDa) is encoded by the human ACKR1 gene. This protein is involved in chemokine binding and sequestration.
National Institutes of Health

Related topics

Related topics

21 relations
ACKR1 geneChemokine Receptor GeneCytokine Receptor GeneCytokine Signaling

Broader (2)

Duffy Blood group systemReceptors, Cell Surface

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Co-expression network analysis identified atypical chemokine receptor 1 (ACKR1) association with lymph node metastasis and prognosis in cervical cancer.
Cervical cancer (CC) is one kind of female cancer. With the development of bioinformatics, targeted specific biomarkers therapy… 
2019
2019
Atypical Chemokine Receptor 1 (DARC/ACKR1) in Breast Tumors Is Associated with Survival, Circulating Chemokines, Tumor-Infiltrating Immune Cells, and African Ancestry
Background: Tumor-specific immune response is an important aspect of disease prognosis and ultimately impacts treatment decisions… 
2018
2018
Dual role for atypical chemokine receptor 1 in myeloid cell hematopoiesis and distribution
Similar to conventional chemokine receptors, atypical chemokine receptors (ACKRs) are cell-surface receptors that possess a seven… 
Highly Cited
2017
Highly Cited
2017
Atypical chemokine receptor 1 on nucleated erythroid cells regulates hematopoiesis
Healthy individuals of African ancestry have neutropenia that has been linked with the variant rs2814778(G) of the gene encoding… 
2017
2017
Abstract 953: Atypical chemokine receptor 1 (ACKR1/DARC) expressing tumors are associated with distinct recruitment of immune cells and increased pro-inflammatory chemokines
Interactions between chemokines and their receptors can improve a host’s anti-tumor response by influencing the targeted… 
2015
2015
Atypical chemokine receptor 1 deficiency reduces atherogenesis in ApoE-knockout mice.
AIMS Atypical chemokine receptor 1 (Ackr1; previously known as the Duffy antigen receptor for chemokines or Darc) is thought to… 
2014
2014
Induction of conformational changes at the N-terminus of herpes simplex virus glycoprotein D upon binding to HVEM and nectin-1.
2014
2014
Regulation of Motor Function and Behavior by Atypical Chemokine Receptor 1
Abstract Atypical Chemokine Receptor 1 (ACKR1), previously known as Duffy Antigen Receptor for Chemokines, stands out among… 
Highly Cited
2005
Highly Cited
2005
Targeted deletion of Plasmodium knowlesi Duffy binding protein confirms its role in junction formation during invasion
Red cell invasion by Plasmodium merozoites involves multiple steps such as attachment, apical reorientation, junction formation… 
Highly Cited
1998
Highly Cited
1998
The Fyx phenotype is associated with a missense mutation in the Fyb allele predicting Arg89Cys in the Duffy glycoprotein
The molecular basis of the three major alleles (Fya/Fyb/Fy) of the Duffy (FY) blood group system has recently been established… 
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