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Variants of RhD – current testing and clinical consequences
- G. Daniels
- Medicine, BiologyBritish journal of haematology
- 1 May 2013
Weak D types 1, 2, and 3 are seldom, if ever, associated with alloanti‐D production, so a policy recommendation would be to treat patients with those D variants as D+, to preserve D− stocks, whereas patients with all other D variants would be treated as D−.
Blood group antibodies and their significance in transfusion medicine.
Effect of high throughput RHD typing of fetal DNA in maternal plasma on use of anti-RhD immunoglobulin in RhD negative pregnant women: prospective feasibility study
- K. Finning, P. Martin, J. Summers, E. Massey, G. Poole, G. Daniels
- MedicineBMJ : British Medical Journal
- 3 April 2008
High throughput RHD genotyping of fetuses in all RhD negative women is feasible and would substantially reduce unnecessary administration of anti-RhD immunoglobulin to RhD positive pregnant women with an RhDnegative fetus.
CD151, the first member of the tetraspanin (TM4) superfamily detected on erythrocytes, is essential for the correct assembly of human basement membranes in kidney and skin.
It is concluded that CD151 is essential for the proper assembly of the glomerular and tubular basement membrane in kidney, has functional significance in the skin, is probably a component of the inner ear, and could play a role in erythropoiesis.
The presence of an RHD pseudogene containing a 37 base pair duplication and a nonsense mutation in africans with the Rh D-negative blood group phenotype.
Existing PCR-based methods for predicting D phenotype from DNA are not suitable for testing Africans or any population containing a substantial proportion of people with African ethnicity, so a new test is developed that detects the 37 bp insert in exon 4 of RHDpsi.
What is a blood group antigen?
A low effectiveness of antiHBc screening for the prevention of non-A,non-B hepatitis in the authors' population is suggested, since ALT screening may detect infective blood units during the delay between infection and seroconversion,* these results confirm the appropriateness of discarding blood units with ALT exceeding the upper limit of normal.
The VS and V blood group polymorphisms in Africans: a serologic and molecular analysis
BACKGROUND: VS and V are common red cell antigens in persons of African origin. The molecular background of these Rh system antigens is poorly understood.
Noninvasive prenatal diagnosis of fetal blood group phenotypes: current practice and future prospects
Fetuses of women with alloantibodies to RhD (D) are at risk from hemolytic disease of the fetus and newborn, but only if the fetal red cells are D‐positive, so it is beneficial to determine fetal D type.
The molecular genetics of blood group polymorphism
- G. Daniels
- BiologyHuman Genetics
- 29 August 2009
Knowledge of the molecular backgrounds of blood group polymorphisms provides a means to predict blood group phenotypes from genomic DNA and has two main applications in transfusion medicine: determination of foetal blood groups to assess whether the foetus is at risk from haemolytic disease and ascertainment of bloodgroup phenotypes in multiply transfused, transfusion-dependent patients, where serological tests are precluded by the presence of donor red cells.