DAPI

Known as: 1H-Indole-6-Carboximidamide, 2-(4-(Aminoiminomethyl)phenyl)-, 2-(4-Carbamimidoylphenyl)-1H-Indole-6-Carboximidamide, 4',6-Diamino-2-Phenylindol 
A lipid soluble fluorochrome dye that binds to adenine-thymine (A-T) rich regions in DNA and, to a lesser extent, RNA. During fluorescence microscopy… (More)
National Institutes of Health

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Fluorescent DyesIndolesIntercalating AgentsSerine Proteinase Inhibitors
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Papers overview

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2011
2011
Labeling nuclear DNA using DAPI.
A number of fluorescent stains are available that label DNA and allow easy visualization of the nucleus in interphase cells and… (More)
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Highly Cited
2009
Highly Cited
2009
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.
Hormone-driven expression of the ERG oncogene after fusion with TMPRSS2 occurs in 30% to 70% of therapy-naive prostate cancers… (More)
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Highly Cited
2008
Highly Cited
2008
High Sensitivity, Quantitative Measurements of Polyphosphate Using a New DAPI-Based Approach
Polyphosphate (poly-P) is an important metabolite and signaling molecule in prokaryotes and eukaryotes. DAPI (4′,6-diamidino-2… (More)
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Highly Cited
2007
Highly Cited
2007
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease.
BACKGROUND Epithelial barrier function is impaired in Crohn's disease. AIM To define the underlying cellular mechanisms with… (More)
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Highly Cited
2005
Highly Cited
2005
Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.
The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel disease… (More)
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Highly Cited
1998
Highly Cited
1998
Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology.
OBJECTIVE To determine which kind of cell death occurs in cartilage from patients with osteoarthritis (OA). METHODS Seven… (More)
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Highly Cited
1998
Highly Cited
1998
NS398, a selective cyclooxygenase-2 inhibitor, induces apoptosis and down-regulates bcl-2 expression in LNCaP cells.
Cyclooxygenase (COX)-2, an inducible enzyme that catalyzes the formation of prostaglandins and other eicosanoids from arachidonic… (More)
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Highly Cited
1993
Highly Cited
1993
Modes of DAPI banding and simultaneous in situ hybridization
By controlling the degree of chromatin denaturation through formamide incubation, or by heat treatment and/or by high pH, three… (More)
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Highly Cited
1992
Highly Cited
1992
Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads.
Single DNA molecules were chemically attached by one end to a glass surface and by their other end to a magnetic bead… (More)
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Highly Cited
1976
Highly Cited
1976
Reverse fluorescent chromosome banding with chromomycin and DAPI
Two DNA binding guanine-specific antibiotics, chromomycin A3 (CMA) and the closely related mithramycin (MM), were used as… (More)
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