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DAPI

Known as: 1H-Indole-6-Carboximidamide, 2-(4-(Aminoiminomethyl)phenyl)-, 2-(4-Carbamimidoylphenyl)-1H-Indole-6-Carboximidamide, 4',6-Diamino-2-Phenylindol 
A lipid soluble fluorochrome dye that binds to adenine-thymine (A-T) rich regions in DNA and, to a lesser extent, RNA. During fluorescence microscopy… Expand
National Institutes of Health

Related topics

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5 relations

Broader (5)

Fluorescent DyesIndolesIntercalating AgentsSerine Proteinase Inhibitors
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer.
Hormone-driven expression of the ERG oncogene after fusion with TMPRSS2 occurs in 30% to 70% of therapy-naive prostate cancers… Expand
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Highly Cited
2007
Highly Cited
2007
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease
Background: Epithelial barrier function is impaired in Crohn’s disease. Aim: To define the underlying cellular mechanisms with… Expand
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Highly Cited
2005
Highly Cited
2005
Spatial Organization and Composition of the Mucosal Flora in Patients with Inflammatory Bowel Disease
ABSTRACT The composition and spatial organization of the mucosal flora in biopsy specimens from patients with inflammatory bowel… Expand
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Highly Cited
2004
Highly Cited
2004
Reverse fluorescent chromosome banding with chromomycin and DAPI
Two DNA binding guanine-specific antibiotics, chromomycin A3 (CMA) and the closely related mithramycin (MM), were used as… Expand
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Highly Cited
1998
Highly Cited
1998
Osteoarthritis chondrocytes die by apoptosis. A possible pathway for osteoarthritis pathology.
OBJECTIVE To determine which kind of cell death occurs in cartilage from patients with osteoarthritis (OA). METHODS Seven… Expand
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Highly Cited
1994
Highly Cited
1994
Development of an rRNA-targeted oligonucleotide probe specific for the genus Acinetobacter and its application for in situ monitoring in activated sludge.
Enhanced biological phosphate removal in an anaerobic-aerobic activated sludge system has generally been ascribed to members of… Expand
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Highly Cited
1992
Highly Cited
1992
Direct mechanical measurements of the elasticity of single DNA molecules by using magnetic beads.
Single DNA molecules were chemically attached by one end to a glass surface and by their other end to a magnetic bead… Expand
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Highly Cited
1992
Highly Cited
1992
Use of a fluorescent redox probe for direct visualization of actively respiring bacteria.
The redox dye 5-cyano-2,3-ditolyl tetrazolium chloride (CTC) was employed for direct epifluorescent microscopic enumeration of… Expand
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Highly Cited
1991
Highly Cited
1991
Mechanism of inhibition of cell proliferation by Vinca alkaloids.
We have used a structure-activity approach to investigate whether the Vinca alkaloids inhibit cell proliferation primarily by… Expand
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Highly Cited
1990
Highly Cited
1990
DAPI staining of fixed cells for high-resolution flow cytometry of nuclear DNA.
  • F. Otto
  • Methods in cell biology
  • 1990
    • Corpus ID: 42106214
Publisher Summary This chapter discusses the use of 4', 6-diamidino-2-phenylindole (DAPI) for flow cytometry (FCM). DAPI has been… Expand
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