Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

DAB(486)-interleukin 2

Known as: DAB(486)-IL-2, DAB486-IL-2, interleukin 2 toxin 
 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (5)

Antineoplastic AgentsAntirheumatic AgentsDiphtheria ToxinInterleukin-2
Expand

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1996
1996
Interleukin-2 receptor-specific fusion toxin inhibits barotrauma-induced arterial atherosclerosis.
Immunocytochemical analyses of human plaques and experimental arterial lesions have implicated activated lymphocytes and… Expand
Is this relevant?
Review
1995
Review
1995
Diphtheria toxin-based receptor-specific chimaeric toxins as targeted therapies.
The results from the phase I/II studies of the intravenous administration of DAB486-IL-2 to patients with refractory… Expand
Is this relevant?
1992
1992
Interleukin 2 receptor targeted fusion toxin (DAB486-IL-2) treatment blocks diabetogenic autoimmunity in non-obese diabetic mice.
Insulin-dependent diabetes mellitus (IDDM) is strikingly similar in the non-obese diabetic (NOD) mouse and humans. In IDDM, the… Expand
Is this relevant?
1992
1992
Intoxication of high affinity IL-2 receptor positive thymocytes blocks early stages of T cell maturation.
Early murine fetal thymocytes express functional, high affinity IL-2 receptors as determined by: (i) the presence of IL-2R beta… Expand
Is this relevant?
1992
1992
Initial clinical experiences with an interleukin-2 fusion toxin (DAB486-IL-2).
 
Is this relevant?
Review
1992
Review
1992
Initial clinical experiences with an interleukin-2 fusion toxin (DAB486-IL-2).
 
Is this relevant?
1991
1991
Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells.
We have used site-directed insertion and point mutagenesis in an attempt to increase the cytotoxic potency and receptor-binding… Expand
Is this relevant?
1990
1990
Structure/function analysis of interleukin-2-toxin (DAB486-IL-2). Fragment B sequences required for the delivery of fragment A to the cytosol of target cells.
We have used cassette and deletion mutagenesis to analyze the structural features of fragment B-related sequences in the fusion… Expand
Is this relevant?
1990
1990
Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194.
We have used site-directed mutagenesis to examine the role played by Arg191, Arg193, and Arg194 of the fusion toxin DAB486-IL-2… Expand
Is this relevant?
1990
1990
Concomitant administration of hapten and IL-2-toxin (DAB486-IL-2) results in specific deletion of antigen-activated T cell clones.
During the proliferative burst after Ag recognition, T cells express cell-surface, high-affinity IL-2R. The importance of IL-2R… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE