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DAB(486)-interleukin 2
Known as:
DAB(486)-IL-2
, DAB486-IL-2
, interleukin 2 toxin
National Institutes of Health
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Related topics
Related topics
5 relations
Broader (5)
Antineoplastic Agents
Antirheumatic Agents
Diphtheria Toxin
Interleukin-2
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1996
1996
Interleukin-2 receptor-specific fusion toxin inhibits barotrauma-induced arterial atherosclerosis.
D. Miller
,
R. Bach
,
+6 authors
M. Farrar
Atherosclerosis
1996
Corpus ID: 29122985
Immunocytochemical analyses of human plaques and experimental arterial lesions have implicated activated lymphocytes and…
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Review
1995
Review
1995
Diphtheria toxin-based receptor-specific chimaeric toxins as targeted therapies.
E. Sweeney
,
J. Murphy
Essays in biochemistry
1995
Corpus ID: 11940443
The results from the phase I/II studies of the intravenous administration of DAB486-IL-2 to patients with refractory…
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1993
1993
DAB486-IL-2 (IL-2-toxin) in combination with low-dose RS-61443 (mycophenolate mofetil) prolongs murine thyroid allograft survival.
D. Hullett
,
A. Landry
,
+4 authors
H. Sollinger
Transplantation proceedings
1993
Corpus ID: 30004310
1992
1992
Interleukin 2 receptor targeted fusion toxin (DAB486‐IL‐2) treatment blocks diabetogenic autoimmunity in non‐obese diabetic mice
A. Pacheco-Silva
,
M. Bastos
,
+5 authors
V. E. Rubin-Kelley
European journal of immunology
1992
Corpus ID: 26888062
Insulin‐dependent diabetes mellitus (IDDM) is strikingly similar in the non‐obese diabetic (NOD) mouse and humans. In IDDM, the…
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1992
1992
Initial clinical experiences with an interleukin-2 fusion toxin (DAB486-IL-2).
Meneghetti Cm
,
LeMaistre Cf
1992
Corpus ID: 77387584
1992
1992
Intoxication of high affinity IL-2 receptor positive thymocytes blocks early stages of T cell maturation.
W. Maśliński
,
J. Murphy
,
T. Strom
International immunology
1992
Corpus ID: 21265052
Early murine fetal thymocytes express functional, high affinity IL-2 receptors as determined by: (i) the presence of IL-2R beta…
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1991
1991
Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells.
T. Kiyokawa
,
D. Williams
,
C. Snider
,
T. Strom
,
J. Murphy
Protein engineering
1991
Corpus ID: 183368
We have used site-directed insertion and point mutagenesis in an attempt to increase the cytotoxic potency and receptor-binding…
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Highly Cited
1990
Highly Cited
1990
Structure/function analysis of interleukin-2-toxin (DAB486-IL-2). Fragment B sequences required for the delivery of fragment A to the cytosol of target cells.
D. Williams
,
C. Snider
,
T. Strom
,
J. Murphy
The Journal of biological chemistry
1990
Corpus ID: 21415929
We have used cassette and deletion mutagenesis to analyze the structural features of fragment B-related sequences in the fusion…
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Highly Cited
1990
Highly Cited
1990
Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194.
D. Williams
,
Z. Wen
,
R. S. Watson
,
J. Boyd
,
T. Strom
,
J. Murphy
The Journal of biological chemistry
1990
Corpus ID: 8769582
We have used site-directed mutagenesis to examine the role played by Arg191, Arg193, and Arg194 of the fusion toxin DAB486-IL-2…
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1990
1990
Concomitant administration of hapten and IL-2-toxin (DAB486-IL-2) results in specific deletion of antigen-activated T cell clones.
M. Bastos
,
O. Pankewycz
,
V. E. Rubin-Kelley
,
J. Murphy
,
T. Strom
Journal of immunology
1990
Corpus ID: 8029180
During the proliferative burst after Ag recognition, T cells express cell-surface, high-affinity IL-2R. The importance of IL-2R…
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