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DAB(486)-interleukin 2

Known as: DAB(486)-IL-2, DAB486-IL-2, interleukin 2 toxin 
National Institutes of Health

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5 relations

Broader (5)

Antineoplastic AgentsAntirheumatic AgentsDiphtheria ToxinInterleukin-2

Papers overview

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1996
1996
Interleukin-2 receptor-specific fusion toxin inhibits barotrauma-induced arterial atherosclerosis.
Review
1995
Review
1995
Diphtheria toxin-based receptor-specific chimaeric toxins as targeted therapies.
The results from the phase I/II studies of the intravenous administration of DAB486-IL-2 to patients with refractory… 
1993
1993
DAB486-IL-2 (IL-2-toxin) in combination with low-dose RS-61443 (mycophenolate mofetil) prolongs murine thyroid allograft survival.
1992
1992
Interleukin 2 receptor targeted fusion toxin (DAB486‐IL‐2) treatment blocks diabetogenic autoimmunity in non‐obese diabetic mice
Insulin‐dependent diabetes mellitus (IDDM) is strikingly similar in the non‐obese diabetic (NOD) mouse and humans. In IDDM, the… 
1992
1992
Initial clinical experiences with an interleukin-2 fusion toxin (DAB486-IL-2).
1992
1992
Intoxication of high affinity IL-2 receptor positive thymocytes blocks early stages of T cell maturation.
Early murine fetal thymocytes express functional, high affinity IL-2 receptors as determined by: (i) the presence of IL-2R beta… 
1991
1991
Protein engineering of diphtheria-toxin-related interleukin-2 fusion toxins to increase cytotoxic potency for high-affinity IL-2-receptor-bearing target cells.
We have used site-directed insertion and point mutagenesis in an attempt to increase the cytotoxic potency and receptor-binding… 
Highly Cited
1990
Highly Cited
1990
Structure/function analysis of interleukin-2-toxin (DAB486-IL-2). Fragment B sequences required for the delivery of fragment A to the cytosol of target cells.
Highly Cited
1990
Highly Cited
1990
Cellular processing of the interleukin-2 fusion toxin DAB486-IL-2 and efficient delivery of diphtheria fragment A to the cytosol of target cells requires Arg194.
We have used site-directed mutagenesis to examine the role played by Arg191, Arg193, and Arg194 of the fusion toxin DAB486-IL-2… 
1990
1990
Concomitant administration of hapten and IL-2-toxin (DAB486-IL-2) results in specific deletion of antigen-activated T cell clones.
During the proliferative burst after Ag recognition, T cells express cell-surface, high-affinity IL-2R. The importance of IL-2R… 
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