Cytochrome P-450 CYP2C8

Known as: Cytochrome P 450 CYP2C8, S-Mephenytoin 4-Hydroxylase, P450 MP-20, Cytochrome 
A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS… (More)
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Lipid-lowering drugs, especially 3-hydroxy-3-methylglutaryl-coenzyme A inhibitors (statins), are widely used in the treatment and… (More)
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Highly Cited
2006
Highly Cited
2006
Our objective was to identify the cytochrome P450 (CYP) enzymes that metabolise pioglitazone and to examine the effects of the… (More)
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Highly Cited
2006
Highly Cited
2006
Gemfibrozil more potently inhibits CYP2C9 than CYP2C8 in vitro, and yet the opposite inhibitory potency is observed in the clinic… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE To retrospectively evaluate the effects of six known allelic variants in the CYP2C8, CYP3A4, CYP3A5, and ABCB1 genes on… (More)
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Highly Cited
2004
Highly Cited
2004
The measurement of the effect of new chemical entities on human cytochrome P450 marker activities using in vitro experimentation… (More)
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Highly Cited
2003
Highly Cited
2003
OBJECTIVE Our objective was to investigate the effects of genetic polymorphisms of cytochrome P450 (CYP) 2C8 on the… (More)
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Highly Cited
2002
Highly Cited
2002
Amodiaquine (AQ) metabolism to N-desethylamodiaquine (DEAQ) is the principal route of disposition in humans. Using human liver… (More)
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Highly Cited
2001
Highly Cited
2001
Cytochrome P450 (CYP) 2C8 is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (Taxol). It… (More)
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Highly Cited
2001
Highly Cited
2001
The expression and inducibility of four CYP2C genes, including CYP2C8, -2C9, -2C18, and -2C19, was investigated in primary… (More)
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Highly Cited
1995
Highly Cited
1995
The membrane-bound endogenous fatty acid arachidonic acid can be released from membranes by phospholipases and then metabolized… (More)
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