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Cytochrome P-450 CYP2C8

Known as: Cytochrome P 450 CYP2C8, S-Mephenytoin 4-Hydroxylase, P450 MP-20, Cytochrome 
A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS… 
National Institutes of Health

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Papers overview

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2015
2015
Association of CYP2C8, CYP2C9 and CYP2J2 gene polymorphisms with myocardial infarction in South Indian population
2014
2014
In Vitro Inhibitory Effects of Scutellarin on Six Human/Rat Cytochrome P450 Enzymes and P-glycoprotein
Inhibition of cytochrome P450 (CYP) and P-glycoprotein (P-gp) are regarded as the most frequent and clinically important… 
Highly Cited
2008
Highly Cited
2008
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke
Objective The biologically active epoxyeicosatrienoic acids have protective vascular effects. CYP2J2, CYP2C8, and CYP2C9 are… 
2006
2006
CYP2C8 polymorphism among the Portuguese
Abstract Cytochrome P450 2C8 (CYP2C8) is a polymorphic phase I drug-metabolising enzyme involved in the metabolism of a wide… 
2005
2005
Biol. Pharm. Bull. 28(5) 882—885 (2005)
blockers, is widely used in the treatment of cardiovascular diseases. Clinical use of this drug has been approved for the… 
2004
2004
Optimizing bacterial expression of catalytically active human cytochromes P450: comparison of CYP2C8 and CYP2C9
Methods for the co-expression in Escherichia coli of human cytochrome P450 (CYP) 2C8 and CYP2C9 with NADPH-cytochrome P450… 
2002
2002
GEMFIBROZIL INHIBITS CYP 2 C 8-MEDIATED CERIVASTATIN METABOLISM IN HUMAN LIVER MICROSOMES
To explore the mechanism of the interaction between gemfibrozil and cerivastatin, the enzyme mapping of the oxidative metabolism… 
Highly Cited
2001
Highly Cited
2001
Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide… 
2000
2000
Inhibition of drug-metabolizing enzyme activity in human hepatic cytochrome P450s by bisphenol A.
Effect of bisphenol A on drug-metabolizing enzyme activities by human hepatic cytochrome P450s (CYP) was investigated. We… 
1986
1986
The murine aromatic hydrocarbon responsiveness locus: a comparison of receptor levels and several inducible enzyme activities among recombinant inbred lines.
The aromatic hydrocarbon responsiveness (Ah) locus has been correlated with genetic differences in the risk of drug toxicity… 
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