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Cytochrome P-450 CYP2C8

Known as: Cytochrome P 450 CYP2C8, S-Mephenytoin 4-Hydroxylase, P450 MP-20, Cytochrome 
A liver microsomal cytochrome P450 hydroxylase that oxidizes a broad spectrum of substrates including STEROIDS, FATTY ACIDS, and XENOBIOTICS… 
National Institutes of Health

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CYP2C8 geneIn BloodProcess of secretionaspects of radiation effects

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CYP2C8 protein, human

Papers overview

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Highly Cited
2012
Highly Cited
2012
Human CYP2C8 Is Post-Transcriptionally Regulated by MicroRNAs 103 and 107 in Human Liver
The CYP2C genes are extensively regulated at the transcriptional stage. The present study shows for the first time that CYP2Cs… 
2010
2010
CYP2C8 Exists as a Dimer in Natural Membranes
CYP2C8 with a modified N-terminal sequence (2C8H) crystallizes as a dimer, but it is not known whether native CYP2C8 exists as a… 
Highly Cited
2008
Highly Cited
2008
Common variation in cytochrome P450 epoxygenase genes and the risk of incident nonfatal myocardial infarction and ischemic stroke
Objective The biologically active epoxyeicosatrienoic acids have protective vascular effects. CYP2J2, CYP2C8, and CYP2C9 are… 
2007
2007
Involvement of Multiple Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes in the in Vitro Metabolism of Muraglitazar
Muraglitazar (Pargluva), a dual α/γ peroxisome proliferator-activated receptor activator, has both glucose- and lipid-lowering… 
2006
2006
The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone
ObjectiveZopiclone is a short acting hypnotic, which is metabolised by cytochrome P450 (CYP) 3A4 and 2C8 in vitro. We studied the… 
Highly Cited
2005
Highly Cited
2005
CYP2C8 polymorphism frequencies among malaria patients in Zanzibar
Objective The determination of the prevalence of the CYP2C8 main alleles in a typical set of malaria patients in Zanzibar, as… 
2005
2005
Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide.
BACKGROUND AND AIMS Gemfibrozil, and particularly its combination with itraconazole, greatly increases the area under the plasma… 
Highly Cited
2003
Highly Cited
2003
Induction of cytochrome P450 enzymes in cultured precision-cut human liver slices.
Precision-cut human liver slices obtained from 11 donors were cultured for 72 h in a defined medium (serum free Williams' medium… 
Highly Cited
2001
Highly Cited
2001
Non-synonymous single nucleotide alterations found in the CYP2C8 gene result in reduced in vitro paclitaxel metabolism.
By sequencing genomic DNA from 73 established cell lines derived from Japanese individuals, we detected 9 single nucleotide… 
1988
1988
The genetics of aflatoxin B1 metabolism. Association of the induction of aflatoxin B1-4-hydroxylase with the transcriptional activation of cytochrome P3-450 gene.
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